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温敏聚合物包埋金纳米棒用于单连续波激光诱导光动力/光热肿瘤治疗。

Thermo-responsive polymer encapsulated gold nanorods for single continuous wave laser-induced photodynamic/photothermal tumour therapy.

机构信息

Department of Respiratory Disease, The First Affiliated Hospital of Bengbu Medical College, Bengbu, 233004, China.

Center for Clinical Medicine of Respiratory Disease (tumor) in Anhui, Bengbu, 233004, China.

出版信息

J Nanobiotechnology. 2021 Feb 8;19(1):41. doi: 10.1186/s12951-020-00754-8.

DOI:10.1186/s12951-020-00754-8
PMID:33557807
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7869504/
Abstract

Owing to strong and tunable surface plasmon resonance (SPR) effect and good biocompatibility, gold nanoparticles have been suggested to be a versatile platform for a broad range of biomedical applications. In this study, a new nanoplatform of thermo-responsive polymer encapsulated gold nanorods incorporating indocyanine green (ICG) was designed to couple the photothermal properties of gold nanorods (AuNRs) and the photodynamic properties of ICG to enhance the photodynamic/photothermal combination therapy (PDT/PTT). In addition to the significantly increased payload and enhancing photostability of ICG, the polymer shell in the nanoplatform also has thermo-responsive characteristics that can control the release of drugs at tumour sites upon the laser irradiation. On the basis of these improvements, the nanoplatform strongly increased drug aggregation at the tumour site and improved the photothermal/photodynamic therapeutic efficacy. These results suggest that this nanoplatform would be a great potential system for tumour imaging and antitumour therapy.

摘要

由于具有较强且可调谐的表面等离子体共振（SPR）效应和良好的生物相容性，金纳米粒子被认为是一种多功能平台，可应用于广泛的生物医学领域。在本研究中，设计了一种新型的温敏聚合物包裹金纳米棒结合吲哚菁绿（ICG）的纳米平台，将金纳米棒（AuNRs）的光热性能和 ICG 的光动力性能结合起来，以增强光动力/光热联合治疗（PDT/PTT）。除了显著增加 ICG 的载药量和提高其光稳定性外，纳米平台中的聚合物壳还具有温敏特性，可以在激光照射下控制药物在肿瘤部位的释放。基于这些改进，该纳米平台可强烈增加药物在肿瘤部位的聚集，并提高光热/光动力治疗效果。这些结果表明，该纳米平台将是一种用于肿瘤成像和抗肿瘤治疗的极具潜力的系统。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78ac/7869504/5049981f12b8/12951_2020_754_Sch1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78ac/7869504/fc9281c54e9f/12951_2020_754_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78ac/7869504/002d4bdbfc58/12951_2020_754_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78ac/7869504/d3d4d5833067/12951_2020_754_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78ac/7869504/cbbf59221b0e/12951_2020_754_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78ac/7869504/f8cf16f998cd/12951_2020_754_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78ac/7869504/efd511cca451/12951_2020_754_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78ac/7869504/8cd3c959b1fe/12951_2020_754_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78ac/7869504/c019e30ff888/12951_2020_754_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78ac/7869504/5049981f12b8/12951_2020_754_Sch1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78ac/7869504/fc9281c54e9f/12951_2020_754_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78ac/7869504/002d4bdbfc58/12951_2020_754_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78ac/7869504/d3d4d5833067/12951_2020_754_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78ac/7869504/cbbf59221b0e/12951_2020_754_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78ac/7869504/f8cf16f998cd/12951_2020_754_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78ac/7869504/efd511cca451/12951_2020_754_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78ac/7869504/8cd3c959b1fe/12951_2020_754_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78ac/7869504/c019e30ff888/12951_2020_754_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78ac/7869504/5049981f12b8/12951_2020_754_Sch1_HTML.jpg

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