使用基于平板电脑的简短认知电池检测阿尔茨海默病生物标志物：对 Aβ 和 tau PET 的敏感性。
Detecting Alzheimer's disease biomarkers with a brief tablet-based cognitive battery: sensitivity to Aβ and tau PET.
机构信息
Department of Neurology, Memory and Aging Center, University of California San Francisco, Box 1207, 675 Nelson Rising Lane, Suite 190, San Francisco, CA, 94158, USA.
Department of Radiology and Biomedical Imaging, University of California San Francisco, 1500 Owens Street, 2nd Fl, San Francisco, CA, 94158, USA.
出版信息
Alzheimers Res Ther. 2021 Feb 8;13(1):36. doi: 10.1186/s13195-021-00776-w.
BACKGROUND
β-amyloid (Aβ) and tau positron emission tomography (PET) detect the pathological changes that define Alzheimer's disease (AD) in living people. Cognitive measures sensitive to Aβ and tau burden may help streamline identification of cases for confirmatory AD biomarker testing.
METHODS
We examined the association of Brain Health Assessment (BHA) tablet-based cognitive measures with dichotomized Aβ -PET status using logistic regression models in individuals with mild cognitive impairment (MCI) or dementia (N = 140; 43 Aβ-, 97 Aβ+). We also investigated the relationship between the BHA tests and regional patterns of tau-PET signal using voxel-wise regression analyses in a subsample of 60 Aβ+ individuals with MCI or dementia.
RESULTS
Favorites (associative memory), Match (executive functions and speed), and Everyday Cognition Scale scores were significantly associated with Aβ positivity (area under the curve [AUC] = 0.75 [95% CI 0.66-0.85]). We found significant associations with tau-PET signal in mesial temporal regions for Favorites, frontoparietal regions for Match, and occipitoparietal regions for Line Orientation (visuospatial skills) in a subsample of individuals with MCI and dementia.
CONCLUSION
The BHA measures are significantly associated with both Aβ and regional tau in vivo imaging markers and could be used for the identification of patients with suspected AD pathology in clinical practice.
背景
β-淀粉样蛋白（Aβ）和 tau 正电子发射断层扫描（PET）可检测活体中定义阿尔茨海默病（AD）的病理变化。对 Aβ 和 tau 负担敏感的认知测量可能有助于简化 AD 生物标志物检测的确诊病例的识别。
方法
我们使用逻辑回归模型，在轻度认知障碍（MCI）或痴呆（N=140；43 例 Aβ-，97 例 Aβ+）患者中，检查了基于 Brain Health Assessment（BHA）片剂的认知测量与 Aβ-PET 状态二分法的关联。我们还在 60 名 MCI 或痴呆的 Aβ+个体的亚样本中，使用体素回归分析研究了 BHA 测试与 tau-PET 信号的区域模式之间的关系。
结果
Favorites（联想记忆）、Match（执行功能和速度）和 Everyday Cognition Scale 评分与 Aβ 阳性显著相关（曲线下面积 [AUC] = 0.75 [95%CI 0.66-0.85]）。我们在 MCI 和痴呆患者的亚样本中发现，Favorites 与内侧颞区、Match 与额顶区、Line Orientation（视觉空间技能）与枕顶区存在显著关联。
结论
BHA 测量与 Aβ 和体内 tau 成像标志物均显著相关，可用于在临床实践中识别疑似 AD 病理的患者。
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