BHA-CS：一种用于阿尔茨海默病及相关疾病的新型认知综合指标。
BHA-CS: A novel cognitive composite for Alzheimer's disease and related disorders.
作者信息
Tsoy Elena, Erlhoff Sabrina J, Goode Collette A, Dorsman Karen A, Kanjanapong Suchanan, Lindbergh Cutter A, La Joie Renaud, Strom Amelia, Rabinovici Gil D, Lanata Serggio C, Miller Bruce L, Tomaszewski Farias Sarah E, Kramer Joel H, Rankin Katherine P, Possin Katherine L
机构信息
Department of Neurology, Memory and Aging Center University of California San Francisco San Francisco California USA.
Department of Radiology and Biomedical Imaging University of California San Francisco San Francisco California USA.
出版信息
Alzheimers Dement (Amst). 2020 Jun 21;12(1):e12042. doi: 10.1002/dad2.12042. eCollection 2020.
INTRODUCTION
Composite scores based on psychometrically rigorous cognitive assessments are well suited for early diagnosis and disease monitoring.
METHODS
We developed and cross-validated the Brain Health Assessment-Cognitive Score (BHA-CS), based on a brief computerized battery, in 451 cognitively normal (CN) and 399 cognitively impaired (mild cognitive impairment [MCI] or dementia) older adults. We investigated its long-term reliability and reliable change indices at longitudinal follow-up (N = 340), and the association with amyloid beta (Aβ) burden in the CN subgroup with Aβ positron emission tomography (N = 119).
RESULTS
The BHA-CS was accurate at detecting cognitive impairment and exhibited excellent long-term stability. Reliable decline over one year was detected in 75% of participants with dementia, 44% with MCI, and 3% of CN. Among CN, the Aβ-positive group showed worse longitudinal performance on the BHA-CS compared to the Aβ-negative group.
DISCUSSION
The BHA-CS is sensitive to cognitive decline in preclinical and prodromal neurodegenerative disease.
引言
基于心理测量学严格的认知评估得出的综合分数非常适合早期诊断和疾病监测。
方法
我们基于简短的计算机化测试组合开发并交叉验证了脑健康评估认知分数（BHA-CS），该测试在451名认知正常（CN）和399名认知受损（轻度认知障碍[MCI]或痴呆）的老年人中进行。我们在纵向随访（N = 340）中研究了其长期可靠性和可靠变化指数，以及在CN亚组中与淀粉样β（Aβ）负荷的关联（Aβ正电子发射断层扫描，N = 119）。
结果
BHA-CS在检测认知障碍方面准确无误，并表现出出色的长期稳定性。在75%的痴呆参与者、44%的MCI参与者和3%的CN参与者中检测到一年以上的可靠下降。在CN中，Aβ阳性组在BHA-CS上的纵向表现比Aβ阴性组更差。
讨论
BHA-CS对临床前和前驱神经退行性疾病的认知下降敏感。
Zotero 插件