Department of Dermatology, University of Cologne, Cologne, Germany.
Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany; Cluster of Excellence Cellular Stress Responses in Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany; Institute for Genetics, University of Cologne, Cologne, Germany; Director's Research Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
J Invest Dermatol. 2021 Apr;141(4S):1063-1070. doi: 10.1016/j.jid.2020.11.014. Epub 2021 Feb 6.
An effective healing response is critical to promote and ensure healthy aging. Major discoveries in both fields-repair and aging-have led to a better understanding of the mechanisms regulating the healing response and of the complexity of the aging process. It will now be important to translate and connect those findings to improve our insights into the decline of regeneration in the elderly. Furthermore, we need to understand how this process can be stalled to maintain and promote tissue resilience. Furthermore, it remains to be explored how the findings in model organisms are conserved in human wounds and how these findings might be translated into the clinic.
有效的愈合反应对于促进和确保健康衰老至关重要。这两个领域（修复和衰老）的重大发现，使我们对调节愈合反应的机制以及衰老过程的复杂性有了更好的理解。现在重要的是将这些发现转化并联系起来，以提高我们对老年人再生能力下降的认识。此外，我们需要了解如何阻止这一过程，以维持和促进组织的弹性。此外，还需要探索模型生物中的发现如何在人类伤口中得到保留，以及这些发现如何转化为临床实践。
