Centre for Dermatology Research, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom; Lydia Becker Institute of Immunology and Inflammation, The University of Manchester, Manchester, United Kingdom; Manchester Institute for Collaborative Research on Aging, The University of Manchester, Manchester, United Kingdom.
Centre for Dermatology Research, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom; Lydia Becker Institute of Immunology and Inflammation, The University of Manchester, Manchester, United Kingdom; NIHR Manchester Biomedical Research Centre, The University of Manchester, Manchester, United Kingdom.
J Invest Dermatol. 2021 Apr;141(4S):1087-1095. doi: 10.1016/j.jid.2020.11.006. Epub 2021 Jan 7.
As global life expectancy continues to rise, we are challenged with maintaining health into old age. One strategy is to target the chronic low-level inflammation associated with aging, termed inflammaging. This is characterized by increased levels of circulating proinflammatory cytokines and a shift toward cellular senescence, changes that are believed to drive many age-associated conditions, including dementia, arthritis, and type 2 diabetes. As with other organs, the skin undergoes functional decline during aging, becoming more fragile and susceptible to infection; however, the contribution of inflammaging is not well-understood. This review article describes the evidence for inflammaging in the skin, its relationship with senescence, and how this relates to declining skin structure and function.
随着全球预期寿命的持续延长，我们面临着在老年时保持健康的挑战。一种策略是针对与衰老相关的慢性低度炎症，即所谓的炎症衰老。其特征是循环中促炎细胞因子水平升高，以及细胞衰老的转变，这些变化被认为是许多与年龄相关的疾病的驱动因素，包括痴呆、关节炎和 2 型糖尿病。与其他器官一样，皮肤在衰老过程中功能下降，变得更加脆弱，容易感染；然而，炎症衰老的作用尚不清楚。这篇综述文章描述了皮肤炎症衰老的证据，它与衰老的关系，以及这与皮肤结构和功能下降的关系。
