Musa Ezekiel, Chivese Tawanda, Werfalli Mahmoud, Matjila Mushi, Norris Shane A, Levitt Naomi
Division of Endocrinology, Department of Medicine, University of Cape Town, Cape Town, Western Cape, South Africa.
Chronic Disease Initiative for Africa, Department of Medicine, University of Cape Town, Cape Town, South Africa.
BMJ Open. 2021 Feb 8;11(2):e040921. doi: 10.1136/bmjopen-2020-040921.
The prevalence of diabetes mellitus globally has increased considerably over the past decades with a resultant increase in the incidence of diabetes-complicated pregnancies. Hyperglycaemia in pregnancy is the most common metabolic complication encountered during pregnancy and is associated with adverse maternal and fetal outcomes. This systematic review aims to examine maternal, fetal, neonatal, childhood and long-term maternal outcomes of hyperglycaemia in pregnancy in Africa.
A systematic review of all studies that investigated hyperglycaemia in pregnancy outcomes, carried out in Africa from 1998 to 2019. A comprehensive search of all published articles indexed in PubMed-MEDLINE, Cochrane Library, Scopus, CINAHL (EBSCOhost), Embase and Web of Science databases will be performed. Studies will be screened for eligibility by title, abstract and full text in duplicate by two independent reviewers. For data where meta-analysis is not possible, narrative analysis will be carried out using themes from data. For data where meta-analysis is possible, random effects meta-analysis will be conducted. This systematic review will be reported according to the Meta-analyses of Observational Studies in Epidemiology.
Ethical approval is not required for this study considering this is a systematic review protocol that uses only published data. The findings of this study will be disseminated through peer-reviewed publications and conference presentations.
CRD42020184573.
在过去几十年中，全球糖尿病的患病率显著上升，导致糖尿病合并妊娠的发病率增加。妊娠期高血糖是妊娠期间最常见的代谢并发症，与母婴不良结局相关。本系统评价旨在研究非洲妊娠期高血糖对母亲、胎儿、新生儿、儿童及母亲长期的影响。
对1998年至2019年在非洲进行的所有调查妊娠期高血糖结局的研究进行系统评价。将全面检索PubMed-MEDLINE、Cochrane图书馆、Scopus、CINAHL（EBSCOhost）、Embase和Web of Science数据库中收录的所有已发表文章。由两名独立评审员对研究进行标题、摘要和全文的重复筛选以确定其是否符合纳入标准。对于无法进行荟萃分析的数据，将使用数据中的主题进行叙述性分析。对于可以进行荟萃分析的数据，将进行随机效应荟萃分析。本系统评价将根据流行病学观察性研究的荟萃分析进行报告。
考虑到本研究是一项仅使用已发表数据的系统评价方案，因此无需伦理批准。本研究的结果将通过同行评审的出版物和会议报告进行传播。
PROSPERO注册号：CRD42020184573。
