Anbarasan Thineskrishna, Wei Cheng, Bamber Jeffrey C, Barr Richard G, Nabi Ghulam
College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh EH8 9YL, UK.
Academic Section of Urology, School of Medicine, University of Dundee, Dundee DD1 4HN, UK.
Cancers (Basel). 2021 Jan 2;13(1):122. doi: 10.3390/cancers13010122.
ultrasound-based shear wave elastography (SWE) can non-invasively assess prostate tissue stiffness. This systematic review aims to evaluate SWE for the detection of prostate cancer (PCa) and compare diagnostic estimates between studies reporting the detection of all PCa and clinically significant PCa (csPCa).
a literature search was performed using the MEDLINE, EMBASE, Cochrane Library, ClinicalTrials.gov, and CINAHL databases. Studies evaluating SWE for the detection of PCa using histopathology as reference standard were included.
16 studies including 2277 patients were included for review. Nine studies evaluated SWE for the detection of PCa using systematic biopsy as a reference standard at the per-sample level, with a pooled sensitivity and specificity of 0.85 (95% CI = 0.74-0.92) and 0.85 (95% CI = 0.75-0.91), respectively. Five studies evaluated SWE for the detection of PCa using histopathology of radical prostatectomy (RP) specimens as the reference standard, with a pooled sensitivity and specificity of 0.71 (95% CI = 0.55-0.83) and 0.74 (95% CI = 0.42-0.92), respectively. Sub-group analysis revealed a higher pooled sensitivity (0.77 vs. 0.62) and specificity (0.84 vs. 0.53) for detection of csPCa compared to all PCa among studies using RP specimens as the reference standard.
SWE is an attractive imaging modality for the detection of PCa.
基于超声的剪切波弹性成像（SWE）可无创评估前列腺组织硬度。本系统评价旨在评估SWE用于检测前列腺癌（PCa）的效果，并比较报告检测所有PCa和临床显著前列腺癌（csPCa）的研究之间的诊断估计值。
使用MEDLINE、EMBASE、Cochrane图书馆、ClinicalTrials.gov和CINAHL数据库进行文献检索。纳入以组织病理学为参考标准评估SWE检测PCa的研究。
纳入16项研究，共2277例患者进行综述。9项研究以系统活检为参考标准，在样本水平评估SWE检测PCa，合并敏感度和特异度分别为0.85（95%CI = 0.74 - 0.92）和0.85（95%CI = 0.75 - 0.91）。5项研究以根治性前列腺切除术（RP）标本的组织病理学为参考标准评估SWE检测PCa，合并敏感度和特异度分别为0.71（95%CI = 0.55 - 0.83）和0.74（95%CI = 0.42 - 0.92）。亚组分析显示，在以RP标本为参考标准的研究中，检测csPCa的合并敏感度（0.77对0.62）和特异度（0.84对0.53）高于所有PCa。
SWE是一种用于检测PCa的有吸引力的成像方式。
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