Department of Cardiology, Toulouse University Hospital, Toulouse, France.
Faculty of Pharmacy, Lebanese University, Beirut, Lebanon.
Med Sci Monit. 2021 Feb 9;27:e928218. doi: 10.12659/MSM.928218.
BACKGROUND Recently, new therapeutic approaches have revolutionized the management of left ventricular dysfunction (LVD) and valvular heart disease (VHD), which are a growing public health problem. In parallel, there are no available epidemiological data about LVD and VHD in developing countries, especially in the Mediterranean area. This retrospective study was conducted at a single center and aimed to evaluate the associations between mitral and aortic valvular disease and left ventricle systolic and diastolic dysfunction in the Lebanese population. MATERIAL AND METHODS A retrospective study was conducted of 4520 consecutive patients aged >18 years who were referred to the Cardiovascular Department of Notre Dame de Secours-University Hospital in Jbeil-Lebanon for transthoracic echocardiography between December 2016 and December 2019. The study population was divided into different groups based on types of LVD and VHD. Left ventricle systolic dysfunction was defined as a left ventricle ejection fraction (EF) ≤40%. Statistical analysis was carried out using SPSS software version 20. RESULTS VHD and systolic dysfunction were more common in men, whereas diastolic dysfunction was more common in women. Being older than age 65 years and smoking were significantly associated with heart failure with preserved EF, whereas female sex was a significant preventive factor against heart failure with reduced EF. Systemic hypertension was correlated with mitral stenosis and tricuspid regurgitation, whereas diabetes mellitus was associated with tricuspid regurgitation (TR). Smoking and older age also appeared to be associated with aortic stenosis. CONCLUSIONS Mitral valve disease (regurgitation and stenosis) was significantly correlated with systolic dysfunction, whereas aortic and mitral regurgitation were associated with diastolic dysfunction. Better monitoring of cardiovascular disease risk factors may lead to a reduced burden of LVD and VHD.
最近，新的治疗方法彻底改变了左心室功能障碍（LVD）和瓣膜性心脏病（VHD）的治疗方法，这是一个日益严重的公共卫生问题。与此同时，在发展中国家，特别是在地中海地区，尚无关于 LVD 和 VHD 的可用流行病学数据。本回顾性研究在一个中心进行，旨在评估黎巴嫩人群中心肌和主动脉瓣膜疾病与左心室收缩和舒张功能障碍之间的关联。
对 2016 年 12 月至 2019 年 12 月期间因经胸超声心动图转诊至黎巴嫩杰贝勒圣母-大学医院心血管科的 4520 例年龄>18 岁的连续患者进行了回顾性研究。研究人群根据 LVD 和 VHD 的类型分为不同组。左心室收缩功能障碍定义为左心室射血分数（EF）≤40%。使用 SPSS 软件版本 20 进行统计分析。
VHD 和收缩功能障碍在男性中更为常见，而舒张功能障碍在女性中更为常见。年龄>65 岁和吸烟与射血分数保留的心衰显著相关，而女性是射血分数降低的心衰的显著预防因素。高血压与二尖瓣狭窄和三尖瓣反流相关，而糖尿病与三尖瓣反流（TR）相关。吸烟和年龄较大也与主动脉瓣狭窄相关。
二尖瓣疾病（反流和狭窄）与收缩功能障碍显著相关，而主动脉瓣和二尖瓣反流与舒张功能障碍相关。更好地监测心血管疾病危险因素可能会降低 LVD 和 VHD 的负担。
