BNT162b2疫苗诱导产生的血清对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）刺突蛋白69/70缺失、E484K和N501Y变体的中和作用
Neutralization of SARS-CoV-2 spike 69/70 deletion, E484K, and N501Y variants by BNT162b2 vaccine-elicited sera.
作者信息
Xie Xuping, Liu Yang, Liu Jianying, Zhang Xianwen, Zou Jing, Fontes-Garfias Camila R, Xia Hongjie, Swanson Kena A, Cutler Mark, Cooper David, Menachery Vineet D, Weaver Scott, Dormitzer Philip R, Shi Pei-Yong
机构信息
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston TX, U.S.A.
Departments of Microbiology and Immunology, University of Texas Medical Branch, Galveston TX, U.S.A.
出版信息
bioRxiv. 2021 Jan 27:2021.01.27.427998. doi: 10.1101/2021.01.27.427998.
We engineered three SARS-CoV-2 viruses containing key spike mutations from the newly emerged United Kingdom (UK) and South African (SA) variants: N501Y from UK and SA; 69/70-deletion+N501Y+D614G from UK; and E484K+N501Y+D614G from SA. Neutralization geometric mean titers (GMTs) of twenty BTN162b2 vaccine-elicited human sera against the three mutant viruses were 0.81- to 1.46-fold of the GMTs against parental virus, indicating small effects of these mutations on neutralization by sera elicited by two BNT162b2 doses.
我们构建了三种含有来自新出现的英国（UK）和南非（SA）变体关键刺突突变的严重急性呼吸综合征冠状病毒2（SARS-CoV-2）病毒：来自英国和南非的N501Y；来自英国的69/70缺失+N501Y+D614G；以及来自南非的E484K+N501Y+D614G。20份BNT162b2疫苗诱导的人血清针对这三种突变病毒的中和几何平均滴度（GMT）是针对亲本病毒GMT的0.81至1.46倍，表明这些突变对两剂BNT162b2诱导的血清中和作用影响较小。
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