Dermatology and Venereology Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.
Dermato-Venereology Clinic, Karolinska University Hospital, Stockholm, Sweden.
J Eur Acad Dermatol Venereol. 2021 May;35(5):1067-1076. doi: 10.1111/jdv.17081. Epub 2021 Jan 6.
Trichodysplasia spinulosa (TS) is a rare dermatological disease caused by TS-associated polyomavirus (TSPyV) in immunosuppressed patients. The seroprevalence of TSPyV in immunocompetent adults is high and the number of immunosuppressed patients developing TS remains low, suggesting that TS is underdiagnosed and/or that additional unknown factors are needed in order to develop TS. There is no well-established treatment for TS, and to date a majority of reported cases have consequently received ineffective therapies, likely due to the unavailability of reviews and recommendations of treatments for TS. The few treatments reported in case reports to be effective include topical cidofovir 3%, reduction of immunosuppression and oral valganciclovir. In this comprehensive review, we present all published cases to date, together with a summary of all treatments for TS categorized by overall clinical efficacy, thus addressing this rare disease and what appears to be its clinically efficacious treatment.
毛发上皮瘤（TS）是一种罕见的皮肤科疾病，由免疫抑制患者中的 TS 相关多瘤病毒（TSPyV）引起。在免疫功能正常的成年人中，TSPyV 的血清流行率较高，而发生 TS 的免疫抑制患者数量仍然较低，这表明 TS 诊断不足和/或需要其他未知因素才能发展为 TS。目前尚无针对 TS 的既定治疗方法，迄今为止，大多数报告的病例都接受了无效的治疗，这可能是由于缺乏对 TS 治疗的审查和建议。在病例报告中报告有效的少数治疗方法包括局部使用西多福韦 3%、减少免疫抑制和口服缬更昔洛韦。在这篇全面的综述中，我们呈现了迄今为止所有已发表的病例，以及根据总体临床疗效对 TS 的所有治疗方法进行的总结，从而解决了这种罕见疾病及其似乎具有临床疗效的治疗方法。
