一名小儿肾移植患者的播散性毛囊角化病采用局部西多福韦和口服来氟米特治疗
Management of Trichodysplasia Spinulosa in a Pediatric Kidney Transplant Patient With Topical Cidofovir and Oral Leflunomide.
作者信息
Hansen Annika M, Mehra Sonia, Bowen Anneli R, Sherbotie Joseph, Cipriano Sarah D
机构信息
Spencer Fox Eccles School of Medicine, Salt Lake City, Utah, USA.
Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
出版信息
Pediatr Transplant. 2025 May;29(3):e70080. doi: 10.1111/petr.70080.
BACKGROUND
This case report describes a 10-year-old male with a history of kidney transplantation who developed trichodysplasia spinulosa (TS), a rare skin disorder associated with immunosuppression.
METHODS
The patient's condition, characterized by follicular papules and keratinous spines primarily on the face, was managed by a multidisciplinary team.
RESULTS
Treatment involved reducing immunosuppression and administering topical cidofovir alongside oral leflunomide, leading to significant clinical improvement over several months.
CONCLUSIONS
This case adds to the literature of TS management and highlights the importance of multidisciplinary care as well as the challenges of treatment accessibility due to insurance limitations.
背景
本病例报告描述了一名10岁男性肾移植受者，其患有一种与免疫抑制相关的罕见皮肤疾病——棘状毛发发育异常（TS）。
方法
该患者的病情以面部为主的毛囊丘疹和角质棘为特征，由多学科团队进行管理。
结果
治疗包括减少免疫抑制，并外用西多福韦和口服来氟米特，在数月内取得了显著的临床改善。
结论
本病例丰富了TS治疗的文献，并强调了多学科护理的重要性以及由于保险限制导致的治疗可及性挑战。
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