School of Agriculture and Food Sciences, University of Queensland, St Lucia, Queensland, Australia.
School of Dentistry, University of Queensland, Herston, Queensland, Australia.
Crit Rev Food Sci Nutr. 2022;62(19):5140-5166. doi: 10.1080/10408398.2021.1882381. Epub 2021 Feb 9.
The last decide has witnessed a growing research interest in the role of dietary phytochemicals in influencing the gut microbiota. On the other hand, recent evidence reveals that dietary phytochemicals exhibit properties of preventing and tackling symptoms of Alzheimer's disease, which is a neurodegenerative disease that has also been linked with the status of the gut microbiota over the last decade. Till now, little serious discussions, however, have been made to link recent understanding of Alzheimer's disease, dietary phytochemicals and the gut microbiota together and to review the roles played by phytochemicals in gut dysbiosis induced pathologies of Alzheimer's disease. Deciphering these connections can provide insights into the development and future use of dietary phytochemicals as anti-Alzheimer drug candidates. This review aims at presenting latest evidence in the modulating role of phytochemicals in the gut microbiota and its relevance to Alzheimer's disease and summarizing the mechanisms behind the modulative activities. Limitations of current research in this field and potential directions will also be discussed for future research on dietary phytochemicals as anti-Alzheimer agents.
最后一个决定见证了人们对膳食植物化学物质在影响肠道微生物群方面的作用越来越感兴趣。另一方面，最近的证据表明，膳食植物化学物质具有预防和解决阿尔茨海默病症状的特性，阿尔茨海默病是一种神经退行性疾病，在过去十年中，它也与肠道微生物群的状况有关。到目前为止，很少有严肃的讨论将最近对阿尔茨海默病、膳食植物化学物质和肠道微生物群的理解联系起来，并回顾植物化学物质在肠道微生物失调引起的阿尔茨海默病病理中的作用。破译这些联系可以深入了解膳食植物化学物质作为抗阿尔茨海默病药物候选物的开发和未来用途。本综述旨在介绍植物化学物质在肠道微生物群中的调节作用及其与阿尔茨海默病的相关性的最新证据，并总结调节活性背后的机制。还将讨论该领域当前研究的局限性以及作为抗阿尔茨海默病药物的膳食植物化学物质未来研究的潜在方向。
