Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Ranchi, Jharkhand, India.
Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Kolkata, West Bengal, India.
J Nutr Biochem. 2024 Jul;129:109622. doi: 10.1016/j.jnutbio.2024.109622. Epub 2024 Mar 13.
Globally, neurodegeneration and cerebrovascular disease are common and growing causes of morbidity and mortality. Pathophysiology of this group of diseases encompasses various factors from oxidative stress to gut microbial dysbiosis. The study of the etiology and mechanisms of oxidative stress as well as gut dysbiosis-induced neurodegeneration in Alzheimer's disease, Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis, autism spectrum disorder, and Huntington's disease has recently received a lot of attention. Numerous studies lend credence to the notion that changes in the intestinal microbiota and enteric neuroimmune system have an impact on the initiation and severity of these diseases. The prebiotic role of polyphenols can influence the makeup of the gut microbiota in neurodegenerative disorders by modulating intracellular signalling pathways. Metabolites of polyphenols function directly as neurotransmitters by crossing the blood-brain barrier or indirectly via influencing the cerebrovascular system. This assessment aims to bring forth an interlink between the consumption of polyphenols biotransformed by gut microbiota which in turn modulate the gut microbial diversity and biochemical changes in the brain. This systematic review will further augment research towards the association of dietary polyphenols in the management of gut dysbiosis-associated neurodegenerative diseases.
在全球范围内，神经退行性疾病和脑血管疾病是发病率和死亡率日益增加的常见原因。这组疾病的病理生理学包括从氧化应激到肠道微生物失调等各种因素。最近，人们对阿尔茨海默病、帕金森病、多发性硬化症、肌萎缩侧索硬化症、自闭症谱系障碍和亨廷顿病中氧化应激和肠道失调引起的神经退行性变的病因和机制的研究产生了浓厚的兴趣。大量研究证实，肠道微生物群和肠神经免疫系统的变化会影响这些疾病的发生和严重程度。多酚的益生元作用可以通过调节细胞内信号通路来影响神经退行性疾病中肠道微生物群的组成。多酚的代谢物通过血脑屏障直接作为神经递质发挥作用，或者通过影响脑血管系统间接发挥作用。本评估旨在阐明肠道微生物群生物转化的多酚的消耗与调节肠道微生物多样性和大脑生化变化之间的联系。本系统评价将进一步加强研究，探讨膳食多酚在管理与肠道微生物失调相关的神经退行性疾病中的作用。
