Hassan Nayera E, El Shebini Salwa M, El-Masry Sahar A, Ahmed Nihad H, Eldeen Ghada Nour, Rasheed Enas A, Aly Manal M, Alian Khhadija M, Afify Mahmoud A S, Khalil Aya
Biological Anthropology Department, Medical Research Division, National Research Centre, Giza, Egypt.
Nutrition and Food ScienceDepartment, National Research Centre, Giza, Egypt.
J Genet Eng Biotechnol. 2021 Feb 9;19(1):28. doi: 10.1186/s43141-021-00127-0.
Although many environmental factors play an important role in bone mass density (BMD) variation, genetic influences account for 60-85% of individual variance. The aim of this study was to find the interaction between some dietary ingredients, vitamin D, estrogen, and obesity polymorphic receptor genes, among a sample of obese Egyptian women. This was a cross sectional study included 97 women (aged 25-60 years). Data on anthropometry, dietary intake, BMD, biochemical, and genetic analyses were collected.
Osteoporosis was high among women had dominant Taq1 vitamin D receptor gene while osteoporosis was less common among the homozygous Apa1 receptor gene women. Both genes in their two forms did not show any effect on serum vitamin D. Heterozygous types of osteoporotic women carried both genes revealed a slight but significant decrease in level of serum calcium. Xba1 estrogen receptor gene was identified only in a homozygous type while the heterozygous Pvu11 estrogen receptors gene has been identified among both osteoporotic and non-osteoporotic women, this gene was associated with higher BMI in both groups compared to the homozygous receptor gene. Mutant types of genotype FTOrs99 and FTOrs80 obesity receptors genes were less common (4.44%, 11%) among participants. Both of these genes were associated with the highest value of BMI and caloric daily intake, fat, and saturated fatty acid that were more prominent among osteoporotic women.
There is significant association between vitamin D, estrogen, obesity receptors genes, special nutrients, and osteoporosis. Increased BMI, calories, and fat intake lead to rise of genetic predisposition and susceptibility to osteoporosis.
尽管许多环境因素在骨密度（BMD）变化中起重要作用，但遗传影响占个体差异的60 - 85%。本研究的目的是在一组肥胖埃及女性样本中，找出某些饮食成分、维生素D、雌激素和肥胖多态性受体基因之间的相互作用。这是一项横断面研究，纳入了97名女性（年龄在25 - 60岁之间）。收集了人体测量学、饮食摄入、骨密度、生化和基因分析的数据。
携带显性Taq1维生素D受体基因的女性骨质疏松发生率较高，而纯合Apa1受体基因的女性中骨质疏松较少见。这两种基因的两种形式对血清维生素D均无影响。携带这两种基因的骨质疏松女性杂合型血清钙水平略有但显著下降。Xba1雌激素受体基因仅在纯合型中被鉴定出来，而杂合型Pvu11雌激素受体基因在骨质疏松和非骨质疏松女性中均有发现，与纯合受体基因相比，该基因在两组中均与较高的体重指数相关。基因型FTOrs99和FTOrs80肥胖受体基因的突变型在参与者中较少见（分别为4.44%和11%）。这两种基因均与最高的体重指数值以及每日热量摄入、脂肪和饱和脂肪酸相关，在骨质疏松女性中更为突出。
维生素D、雌激素、肥胖受体基因、特殊营养素与骨质疏松之间存在显著关联。体重指数、热量和脂肪摄入量增加会导致遗传易感性增加和患骨质疏松症的易感性上升。
