CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, Gansu, 730000, China.
University of Chinese Academy of Sciences, Beijing, 100049, China.
Mikrochim Acta. 2021 Feb 9;188(3):76. doi: 10.1007/s00604-021-04738-9.
A general method was developed for preparing a metal-organic framework-polymer composite coated silica core-shell stationary phase. Silica microspheres were comodified with metal-organic framework and polyvinylpyrrolidone rather than the in situ method of silica modification by original metal-organic framework particles. Metal-organic framework particles and polyvinylpyrrolidone on silica surface were beneficial to suppress silanol activity and enhance composite material tolerance, as well as increasing the water compatibility of the original metal-organic framework-based stationary phases. The stationary phase exhibited superior hydrophilic and hydrophobic performance in terms of separation for various analytes including seven alkaloids, six sulfonamides, five antibiotics, and five polycyclic aromatic hydrocarbons. Moreover, the composite material also showed excellent stability with the relative standard deviation of the retention time of 0.4 to 0.7%. The separation performance with real samples proved that the column has good practical application potential. In summary, the poposed method provides a general way for preparing metal-organic framework-polymer composite material and changed the current status of original metal-organic framework particles modified silica as a single mode chromatographic stationary phase.
一种通用的方法被开发用于制备金属有机骨架-聚合物复合涂层二氧化硅核壳固定相。通过金属有机骨架和聚乙烯吡咯烷酮对二氧化硅微球进行共修饰，而不是通过原始金属有机骨架颗粒原位修饰二氧化硅的方法。金属有机骨架颗粒和聚乙烯吡咯烷酮在二氧化硅表面有利于抑制硅醇活性并增强复合材料的耐受性，同时提高了原始基于金属有机骨架的固定相的亲水性。该固定相在分离各种分析物（包括七种生物碱、六种磺胺类药物、五种抗生素和五种多环芳烃）方面表现出优异的亲水和疏水性能。此外，该复合材料还表现出优异的稳定性，保留时间的相对标准偏差为 0.4 至 0.7%。实际样品的分离性能证明了该柱具有良好的实际应用潜力。总之，该方法为制备金属有机骨架-聚合物复合材料提供了一种通用方法，并改变了原始金属有机骨架颗粒修饰二氧化硅作为单一模式色谱固定相的现状。
