CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, China.
Talanta. 2021 Jan 15;222:121603. doi: 10.1016/j.talanta.2020.121603. Epub 2020 Sep 11.
The core-shell composites were first prepared by surface modification of silica spheres with two-dimensional MOF-FDM-23 nanosheets via a simple approach. The successful immobilization of 2D MOF-FDM-23 on the silica (2D MOF-FDM-23@silica) was confirmed by series of method including elemental analysis, X-ray photoelectron spectroscopy (XPS), Fourier-transform infrared (FT-IR) transmission electron microscopy (TEM), scanning electron microscopy (SEM), powder X-ray diffraction (XRD) and the Brunauer-Emmett-Teller (BET). The obtained material showed excellent separation performance for multiple polar compounds such as sulfonamides, alkaloids, antibiotic and amino acid compounds etc. In addition, it was found to be superior to most reported MOF-based stationary phases in terms of separation performance, preparative reproducibility and chromatographic stability. The reproducibility of material preparation was demonstrated by the difference in retention time of the same mixture on three batches of the material at different times. The relative standard deviation (RSD) of the retention time for preparation repeatability was found to range from 0.5% to 1.4%. In short, the core-shell composite material prepared by this method broadened the application of MOF-based composites as chromatography stationary phase, and significantly developed the field of 2D MOF nanosheets in chromatography.
首先通过简单的方法将二维 MOF-FDM-23 纳米片表面修饰到硅球上，制备核壳复合材料。通过元素分析、X 射线光电子能谱（XPS）、傅里叶变换红外（FT-IR）透射电子显微镜（TEM）、扫描电子显微镜（SEM）、粉末 X 射线衍射（XRD）和 Brunauer-Emmett-Teller（BET）等一系列方法证实了二维 MOF-FDM-23 在二氧化硅（2D MOF-FDM-23@二氧化硅）上的成功固定。所得到的材料对多种极性化合物如磺胺类、生物碱、抗生素和氨基酸类化合物等表现出优异的分离性能。此外，在分离性能、制备重现性和色谱稳定性方面，它优于大多数报道的基于 MOF 的固定相。材料制备的重现性通过在不同时间的三批材料上同一混合物的保留时间的差异来证明。发现制备重复性的保留时间的相对标准偏差（RSD）范围为 0.5%至 1.4%。总之，通过这种方法制备的核壳复合材料拓宽了基于 MOF 的复合材料作为色谱固定相的应用，并显著发展了二维 MOF 纳米片在色谱领域的应用。
