心肺适能、炎症与肺炎发病风险。
Cardiorespiratory Fitness, Inflammation, and the Incident Risk of Pneumonia.
机构信息
Department of Sport Science, University of Seoul, Seoul, South Korea (Dr Jae); Department of Exercise Science, Syracuse University, Syracuse, New York (Dr Heffernan); Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland (Drs Kurl and Laukkanen); National Institute for Health Research Bristol Biomedical Research Centre, University Hospitals Bristol and Weston NHS Foundation Trust and the University of Bristol, and Translational Health Sciences, Bristol Medical School, University of Bristol, Southmead Hospital, Bristol, England (Dr Kunutsor); Department of Cardiovascular Disease, Mayo Clinic, Rochester, Minnesota (Drs Kim and Johnson); Preventive Cardiology and Cardiac Rehabilitation, Beaumont Health, Royal Oak, Michigan (Dr Franklin); and Institute of Clinical Medicine, Department of Medicine, University of Eastern Finland, Kuopio, and Central Finland Health Care District Hospital District, Department of Medicine, Jyväskylä, Finland District, Jyväskylä, Finland (Dr Laukkanen).
出版信息
J Cardiopulm Rehabil Prev. 2021 May 1;41(3):199-201. doi: 10.1097/HCR.0000000000000581.
INTRODUCTION
Both inflammation and cardiorespiratory fitness (CRF) are associated with the risk of respiratory infections. To clarify the hypothesis that CRF attenuates the incident risk of pneumonia due to inflammation, we conducted a prospective study examining the independent and joint associations of inflammation and CRF on the risk of pneumonia in a population sample of 2041 middle-aged men.
METHODS
Cardiorespiratory fitness was directly measured as peak oxygen uptake (V˙o2peak) during progressive exercise testing to volitional fatigue, and categorized into tertiles. Inflammation was defined by high-sensitivity C-reactive protein (hsCRP). Pneumonia cases were identified by internal medicine physicians using the International Classification of Diseases codes in clinical practice.
RESULTS
During a median follow-up of 27 yr, 432 pneumonia cases were recorded. High hsCRP and CRF were associated with a higher risk (HR = 1.38; 95% CI, 1.02-1.88) and a lower risk of pneumonia (HR = 0.55; CI, 0.39-0.76) after adjusting for potential confounders, respectively. Compared with normal hsCRP-Fit, moderate to high hsCRP-Unfit had an increased risk of pneumonia (HR = 1.63; CI, 1.21-2.20), but moderate to high hsCRP-Fit was not associated with an increased risk of pneumonia (HR = 1.25; CI, 0.93-1.68).
CONCLUSIONS
High CRF attenuates the increased risk of pneumonia due to inflammation. These findings have potential implications for the prevention of respiratory infection characterized by systemic inflammation, such as coronavirus disease-2019 (COVID-19).
简介
炎症和心肺功能（CRF）都与呼吸道感染的风险相关。为了阐明 CRF 是否可以减轻炎症导致肺炎发病风险这一假说，我们对 2041 名中年男性进行了一项前瞻性研究，该研究考察了炎症和 CRF 对肺炎发病风险的独立和联合影响。
方法
心肺功能是通过在逐渐递增的运动测试中测量到的峰值摄氧量（V˙o2peak）直接得出的，并按 tertiles 进行分类。炎症定义为高敏 C 反应蛋白（hsCRP）。肺炎病例通过内科医生使用国际疾病分类代码在临床实践中进行识别。
结果
在中位随访 27 年期间，共记录到 432 例肺炎病例。在调整了潜在混杂因素后，高 hsCRP 和 CRF 与更高的肺炎发病风险（HR = 1.38；95%CI，1.02-1.88）和更低的肺炎发病风险（HR = 0.55；CI，0.39-0.76）相关。与正常 hsCRP-健康组相比，中至高 hsCRP-不健康组肺炎发病风险增加（HR = 1.63；CI，1.21-2.20），但中至高 hsCRP-健康组与肺炎发病风险增加无关（HR = 1.25；CI，0.93-1.68）。
结论
高 CRF 可减轻炎症导致的肺炎发病风险增加。这些发现对于预防以全身炎症为特征的呼吸道感染（如新型冠状病毒病 2019（COVID-19））具有潜在意义。
Zotero 插件