Fujian Provincial Engineering Technology Research Center of Marine Functional Food, College of Food and Biological Engineering, Jimei University, Xiamen, 361021, China.
Graduate Institute of Biomedical Engineering, National Chung Hsing University, Taichung, 402, Taiwan.
Mol Nutr Food Res. 2021 Mar;65(6):e2000780. doi: 10.1002/mnfr.202000780. Epub 2021 Feb 25.
Although pickled radish is widely consumed worldwide, few studies have investigated the nutritional benefits of bioactive compounds extracted from pickled radish. In this study, the authors investigate the relationship among dietary phenolic compounds, lipid accumulation, and gut microbiota.
Three phenolic compounds 2,6-dihydroxyacetophenone (DHAP), 4-hydroxyphenethyl alcohol (4-HPEA), and 4-hydroxybenzaldehyde (HBA) are extracted from pickled radish. LO2 cells treated with free fatty acid are first used to explore the impact of the above three compounds at different doses on reducing lipid levels. The effects of the three compounds on obesity and the gut microbiota are further investigated in high-fat diet (HFD)-induced KM mice. Results show that three compounds inhibited the lipid accumulation in LO2 cells. The results of animal experiments reveal that three compounds prevented body weight gain and significantly decreased serum lipid levels. Treatment with DHAP, HPEA, and HBA reversed gut microbiome dysbiosis in HFD-induced mice. The three phenolic compounds increase Odoribacter, and decrease Helicobacter and Mucispirillum. Notably, DHAP and HBA reduce the HFD-induced increase in the Firmicutes/Bacteroidetes ratio.
These data suggest that phenolic compounds extracted from pickled radish possess excellent lipid-lowering capacity, providing a theoretical basis for further analysis of the nutritional value of pickled radish.
尽管泡菜萝卜在世界范围内广泛食用，但很少有研究调查从泡菜萝卜中提取的生物活性化合物的营养价值。在这项研究中，作者研究了膳食酚类化合物、脂肪积累和肠道微生物群之间的关系。
从泡菜萝卜中提取了三种酚类化合物：2,6-二羟基苯乙酮（DHAP）、4-羟基苯乙醇（4-HPEA）和 4-羟基苯甲醛（HBA）。首先用游离脂肪酸处理 LO2 细胞，以探讨上述三种化合物在不同剂量下对降低脂质水平的影响。进一步在高脂饮食（HFD）诱导的 KM 小鼠中研究了三种化合物对肥胖和肠道微生物群的影响。结果表明，三种化合物抑制了 LO2 细胞中的脂质积累。动物实验结果表明，三种化合物可防止体重增加，并显著降低血清脂质水平。DHAP、HPEA 和 HBA 的处理可逆转 HFD 诱导的小鼠肠道微生物群失调。三种酚类化合物增加了 Odoribacter，减少了 Helicobacter 和 Mucispirillum。值得注意的是，DHAP 和 HBA 降低了 HFD 诱导的厚壁菌门/拟杆菌门比值的增加。
这些数据表明，从泡菜萝卜中提取的酚类化合物具有优异的降脂能力，为进一步分析泡菜萝卜的营养价值提供了理论依据。
