Ludlum D B, Colinas R J, Kirk M C, Mehta J R
Department of Pharmacology, University of Massachussetts Medical School, Worcester 01655.
Carcinogenesis. 1988 Apr;9(4):593-6. doi: 10.1093/carcin/9.4.593.
Metronidazole, which is known to react with DNA under certain conditions, forms an adduct with guanosine in the presence of the reducing agent, sodium dithionite. This product has been purified by HPLC, characterized by UV and fast atom bombardment mass spectrometry, and tentatively identified as 1-(2-hydroxyethyl)-2-methyl-5-(N2-guanosinylamino)imidazole. This adduct is very unstable and decomposes to a variety of products including guanosine. Formation of this and similar DNA adducts from metronidazole in vivo, and the decomposition of these products, are probably both strongly dependent on details of intracellular metabolism.
已知甲硝唑在某些条件下会与DNA发生反应，在还原剂连二亚硫酸钠存在的情况下，它会与鸟苷形成加合物。该产物已通过高效液相色谱法纯化，通过紫外光谱和快原子轰击质谱进行表征，并初步鉴定为1-(2-羟乙基)-2-甲基-5-(N2-鸟苷基氨基)咪唑。这种加合物非常不稳定，会分解为包括鸟苷在内的多种产物。甲硝唑在体内形成这种及类似的DNA加合物以及这些产物的分解，可能都强烈依赖于细胞内代谢的细节。
