文献检索，用中文搜 PubMed

Suppr 超能文献

核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Boldyrev A A, Dupin A M, Pindel E V, Severin S E

Department of Biochemistry, School of Biology, Moscow State University, U.S.S.R.

Comp Biochem Physiol B. 1988;89(2):245-50. doi: 10.1016/0305-0491(88)90218-0.

Ascorbate-dependent peroxidation of lipid components of biological membranes is inhibited by the natural histidine-containing dipeptides, carnosine and anserine, used at physiological concentrations. 2. Carnosine and anserine exhibit an equal antioxidative activity, whereas the preventing effect of homocarnosine is manifested only at low concentrations of oxidized lipid material. 3. The inhibiting effect of the dipeptides is enhanced either by the rise in the dipeptide concentration or by the decrease in the level of membrane components. 4. Addition of the dipeptides results in a marked decrease in the level of primary molecular products of lipid peroxidation. 5. In this case the optical spectrum of primary molecular products of polyunsaturated fatty acids changes significantly.

生理浓度下使用的天然含组氨酸二肽肌肽和鹅肌肽可抑制生物膜脂质成分的抗坏血酸依赖性过氧化反应。2. 肌肽和鹅肌肽具有同等的抗氧化活性，而高肌肽的预防作用仅在低浓度氧化脂质物质时才表现出来。3. 二肽浓度升高或膜成分水平降低都会增强二肽的抑制作用。4. 添加二肽会导致脂质过氧化初级分子产物水平显著降低。5. 在这种情况下，多不饱和脂肪酸初级分子产物的光谱会发生显著变化。

Boldyrev A A, Dupin A M, Pindel E V, Severin S E

Department of Biochemistry, School of Biology, Moscow State University, U.S.S.R.

Comp Biochem Physiol B. 1988;89(2):245-50. doi: 10.1016/0305-0491(88)90218-0.

Ascorbate-dependent peroxidation of lipid components of biological membranes is inhibited by the natural histidine-containing dipeptides, carnosine and anserine, used at physiological concentrations. 2. Carnosine and anserine exhibit an equal antioxidative activity, whereas the preventing effect of homocarnosine is manifested only at low concentrations of oxidized lipid material. 3. The inhibiting effect of the dipeptides is enhanced either by the rise in the dipeptide concentration or by the decrease in the level of membrane components. 4. Addition of the dipeptides results in a marked decrease in the level of primary molecular products of lipid peroxidation. 5. In this case the optical spectrum of primary molecular products of polyunsaturated fatty acids changes significantly.

生理浓度下使用的天然含组氨酸二肽肌肽和鹅肌肽可抑制生物膜脂质成分的抗坏血酸依赖性过氧化反应。2. 肌肽和鹅肌肽具有同等的抗氧化活性，而高肌肽的预防作用仅在低浓度氧化脂质物质时才表现出来。3. 二肽浓度升高或膜成分水平降低都会增强二肽的抑制作用。4. 添加二肽会导致脂质过氧化初级分子产物水平显著降低。5. 在这种情况下，多不饱和脂肪酸初级分子产物的光谱会发生显著变化。