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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Boldyrev A A, Dupin A M, Batrukova M A, Bavykina N I, Korshunova G A

School of Biology, M. V. Lomonosov Moscow State University, USSR.

Comp Biochem Physiol B. 1989;94(2):237-40. doi: 10.1016/0305-0491(89)90339-8.

The antioxidative activity of carnosine and 16 related compounds, both synthetic and natural, was determined. 2. The antioxidative effect was estimated by the ability of the dipeptides to prevent MDA accumulation in the course of LPO induced in rabbit sarcoplasmic reticulum membranes by the Fe2+ ascorbate system. 3. It was found that the antioxidative effect comparable to that of carnosine was exerted by water-soluble (cyclo-L-histidyl-L-proline) and alcohol-soluble (cyclo-L-histidyl-L-phenilalanine) dipeptides as well as by the histidine-free cyclodipeptides (cyclo-L-tyrosyl-L-proline). 4. However, in contrast to its synthetic analogs, carnosine not only inhibited the LPO, but also diminished the level of products accumulated during membrane lipid peroxidation.

测定了肌肽及16种相关化合物（包括合成的和天然的）的抗氧化活性。2. 通过二肽在Fe2+ -抗坏血酸体系诱导兔肌浆网膜发生脂质过氧化过程中防止丙二醛积累的能力来评估抗氧化效果。3. 发现水溶性二肽（环-L-组氨酰-L-脯氨酸）、醇溶性二肽（环-L-组氨酰-L-苯丙氨酸）以及不含组氨酸的环二肽（环-L-酪氨酰-L-脯氨酸）具有与肌肽相当的抗氧化作用。4. 然而，与它的合成类似物不同，肌肽不仅抑制脂质过氧化，还降低了膜脂质过氧化过程中积累的产物水平。

Boldyrev A A, Dupin A M, Batrukova M A, Bavykina N I, Korshunova G A

School of Biology, M. V. Lomonosov Moscow State University, USSR.

Comp Biochem Physiol B. 1989;94(2):237-40. doi: 10.1016/0305-0491(89)90339-8.

The antioxidative activity of carnosine and 16 related compounds, both synthetic and natural, was determined. 2. The antioxidative effect was estimated by the ability of the dipeptides to prevent MDA accumulation in the course of LPO induced in rabbit sarcoplasmic reticulum membranes by the Fe2+ ascorbate system. 3. It was found that the antioxidative effect comparable to that of carnosine was exerted by water-soluble (cyclo-L-histidyl-L-proline) and alcohol-soluble (cyclo-L-histidyl-L-phenilalanine) dipeptides as well as by the histidine-free cyclodipeptides (cyclo-L-tyrosyl-L-proline). 4. However, in contrast to its synthetic analogs, carnosine not only inhibited the LPO, but also diminished the level of products accumulated during membrane lipid peroxidation.

测定了肌肽及16种相关化合物（包括合成的和天然的）的抗氧化活性。2. 通过二肽在Fe2+ -抗坏血酸体系诱导兔肌浆网膜发生脂质过氧化过程中防止丙二醛积累的能力来评估抗氧化效果。3. 发现水溶性二肽（环-L-组氨酰-L-脯氨酸）、醇溶性二肽（环-L-组氨酰-L-苯丙氨酸）以及不含组氨酸的环二肽（环-L-酪氨酰-L-脯氨酸）具有与肌肽相当的抗氧化作用。4. 然而，与它的合成类似物不同，肌肽不仅抑制脂质过氧化，还降低了膜脂质过氧化过程中积累的产物水平。