Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA.
Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA.
Curr Opin Microbiol. 2021 Apr;60:8-15. doi: 10.1016/j.mib.2021.01.005. Epub 2021 Feb 6.
Methanogenesis is a widespread metabolism of evolutionary and environmental importance that is likely to have originated on early Earth. Microorganisms that perform methanogenesis, termed methanogens, belong exclusively to the domain Archaea. Despite maintaining eukaryotic transcription machinery and homologs of bacterial regulators, archaeal transcription and gene regulation appear to be distinct from either domain. While genes involved in methanogenic metabolism have been identified and characterized, their regulation in response to both extracellular and intracellular signals is less understood. Here, we review recent reports on transcriptional regulation of methanogenesis using two model methanogens, Methanococcus maripaludis and Methanosarcina acetivorans, and highlight directions for future research in this nascent field.
产甲烷作用是一种广泛存在的代谢作用，具有进化和环境重要性，可能起源于早期地球。进行产甲烷作用的微生物被称为产甲烷菌，它们专门属于古菌域。尽管古菌维持着真核转录机制和细菌调节剂的同源物，但古菌的转录和基因调控似乎与两个域都不同。虽然已经鉴定和描述了参与产甲烷代谢的基因，但它们对外界和细胞内信号的反应的调节还不太了解。在这里，我们综述了使用两种模式产甲烷菌 Methanococcus maripaludis 和 Methanosarcina acetivorans 进行产甲烷作用转录调控的最新报告，并强调了这一新兴领域未来研究的方向。
