Division of Clinical Data Analytics and Decision Support, Department of Medicine, College of Medicine-Phoenix, University of Arizona, Phoenix, AZ; AZCERT, Oro Valley, AZ.
AZCERT, Oro Valley, AZ.
Trends Cardiovasc Med. 2018 Feb;28(2):94-99. doi: 10.1016/j.tcm.2017.07.010. Epub 2017 Aug 1.
Since the 1990s, when numerous non-cardiac drugs were first recognized to have the potential to prolong the QT interval and cause torsades de pointes (TdP), clinicians, drug regulators, drug developers, and clinical investigators have become aware of the complexities of assessing evidence and determining TdP causality for the many drugs being marketed or under development. To facilitate better understanding, the Arizona Center for Education and Research on Therapeutics, known as AZCERT, has developed the CredibleMeds.org website which includes QTdrugs, a listing of over 220 drugs placed in four risk categories based on their association with QT prolongation and TdP. Since the site was launched in 1999, it has become the single and most reliable source of information of its kind for patients, healthcare providers, and research scientists. Over 96,000 registered users rely on the QTdrugs database as their primary resource to inform their medication use, their prescribing or their clinical research into the impact of QT-prolonging drugs and drug-induced arrhythmias. The QTdrugs lists are increasingly used as the basis for clinical decision support systems in healthcare and for metrics of prescribing quality by healthcare insurers. A free smartphone app and an application program interface enable rapid and mobile access to the lists. Also, the CredibleMeds website offers numerous educational resources for patients, educators and healthcare providers that foster the safe use of medications.
自 20 世纪 90 年代以来，当许多非心脏药物首次被发现有可能延长 QT 间期并导致尖端扭转型室性心动过速（TdP）时，临床医生、药物监管机构、药物开发商和临床研究人员已经意识到评估证据和确定许多正在上市或开发的药物的 TdP 因果关系的复杂性。为了便于更好地理解，亚利桑那州治疗教育和研究中心（称为 AZCERT）开发了 CredibleMeds.org 网站，其中包括 QTdrugs，这是一个列出了 220 多种药物的清单，根据它们与 QT 延长和 TdP 的关联，将这些药物分为四个风险类别。自 1999 年该网站推出以来，它已成为患者、医疗保健提供者和研究科学家获取此类信息的单一且最可靠的来源。超过 96,000 名注册用户依赖 QTdrugs 数据库作为其主要资源，以告知他们的用药、处方或他们对延长 QT 药物和药物引起的心律失常的临床研究。QTdrugs 清单越来越多地被用作医疗保健中的临床决策支持系统的基础，以及医疗保健保险公司衡量处方质量的指标。一个免费的智能手机应用程序和一个应用程序编程接口使快速和移动访问列表成为可能。此外，CredibleMeds 网站还为患者、教育工作者和医疗保健提供者提供了许多教育资源，以促进药物的安全使用。
