Mohamed Maged E, Abduldaium Mohamed S, Younis Nancy S
Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia.
Department of Pharmacognosy, College of Pharmacy, Zagazig University, Zagazig 44519, Egypt.
Life (Basel). 2021 Feb 5;11(2):120. doi: 10.3390/life11020120.
Myocardial infarction (MI), a life-threatening disorder, arises from the imbalance between oxygen supply and myocardial demand. Linalool is a naturally occurring monoterpenes with proved numerous pharmacological actions. This study investigated the cardioprotective effect of Linalool on isoproterenol (ISO)-induced MI in rat models and explored part of the underlying molecular mechanisms.
Rats were divided into five groups; groups I and II served as normal and linalool control groups, Group III administered ISO alone; groups V and VI received two different doses of Linalool and were challenged by ISO. Different biochemical parameters were determined, including hemodynamic, infarction size, cardiac enzymes, apoptotic markers, and inflammatory mediators.
Linalool limited the infarcted area size and diminished the elevated cardiac enzymes. Linalool escalated HO-1 and Nrf2, both nuclear and cytosol fractions, and reduced Keap 1. Linalool enhanced cardiac antioxidant activities, reduced inflammatory cytokines (tumor necrosis factor-alpha (TNF-α), nuclear factor-κ-B (NF-κB), interleukin 1 beta (IL-1β), interleukin 6 (IL-6)), apoptotic markers (Caspase-3, Caspase-9, and Bax), and elevated Bcl2.
Linalool could act as an effective cardioprotective agent in the MI model through improving the oxidative condition, probably via the Nrf2/HO-1 pathway and by abolishing both apoptotic and inflammatory responses.
心肌梗死（MI）是一种危及生命的疾病，由氧气供应与心肌需求之间的失衡引起。芳樟醇是一种天然存在的单萜，已被证明具有多种药理作用。本研究调查了芳樟醇对异丙肾上腺素（ISO）诱导的大鼠心肌梗死模型的心脏保护作用，并探讨了部分潜在的分子机制。
将大鼠分为五组；第一组和第二组作为正常对照组和芳樟醇对照组，第三组单独给予ISO；第四组和第五组接受两种不同剂量的芳樟醇，并接受ISO刺激。测定了不同的生化参数，包括血流动力学、梗死面积、心肌酶、凋亡标志物和炎症介质。
芳樟醇限制了梗死面积大小，并降低了升高的心肌酶。芳樟醇使核和细胞质部分的HO-1和Nrf2升高，并降低了Keap 1。芳樟醇增强了心脏抗氧化活性，降低了炎症细胞因子（肿瘤坏死因子-α（TNF-α）、核因子-κB（NF-κB）、白细胞介素1β（IL-1β）、白细胞介素6（IL-6））、凋亡标志物（半胱天冬酶-3、半胱天冬酶-9和Bax），并升高了Bcl2。
芳樟醇可能通过Nrf2/HO-1途径改善氧化状态，并消除凋亡和炎症反应，从而在心肌梗死模型中作为一种有效的心脏保护剂发挥作用。
