Zinzuvadia Diwyanshi, Suthar Jalpa, Patel Alkeshkumar, Shah Umang, Solanki Nilay, Koria Hardik
Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology, CHARUSAT Campus Changa 388421, India.
Am J Transl Res. 2024 Jun 15;16(6):2290-2300. doi: 10.62347/GHIX8452. eCollection 2024.
To evaluate the cardioprotective effects of in isoproterenol-induced myocardial infarction in rats and to evaluate the role of phosphatidylinositol 3-kinases (PI3K) in cardioprotection.
The protective effect of the hydroalcoholic leaf extract of (LEGP) on the heart was investigated against isoproterenol (ISO)-induced MI in rats. Preliminary phytochemical screening was performed followed by molecular docking. For the in vivo studies Wistar albino rats (Male) were divided among different groups. Different parameters were evaluated such as heart weight index, Electrocardiogram (ECG) analysis, triphenyl tetrazolium chloride assay, cardiac enzyme markers, oxidative stress, antioxidant enzymes, PI3K levels, and histopathology of cardiac tissue.
Results showed that LEGP improved the electrocardiogram, reduced infarct size, and decreased the levels of cardiac enzyme markers and oxidative stress, while antioxidant enzymes and PI3K levels were increased.
LEGP protected the heart against ISO-induced MI in rats by improving hemodynamic, biochemical and histological attributes. These protective effects were produced by the phytoconstituents of the LEGP through modulation of the PI3K signalling pathway.
评估[植物名称]水醇叶提取物（LEGP）对异丙肾上腺素诱导的大鼠心肌梗死的心脏保护作用，并评估磷脂酰肌醇3激酶（PI3K）在心脏保护中的作用。
研究了LEGP对大鼠异丙肾上腺素（ISO）诱导的心肌梗死的心脏保护作用。进行了初步的植物化学筛选，随后进行分子对接。对于体内研究，将雄性Wistar白化大鼠分为不同组。评估了不同参数，如心脏重量指数、心电图（ECG）分析、氯化三苯基四氮唑试验、心脏酶标志物、氧化应激、抗氧化酶、PI3K水平以及心脏组织的组织病理学。
结果表明，LEGP改善了心电图，减小了梗死面积，降低了心脏酶标志物水平和氧化应激，同时抗氧化酶和PI3K水平升高。
LEGP通过改善血流动力学、生化和组织学特征保护大鼠心脏免受ISO诱导的心肌梗死。这些保护作用是由LEGP的植物成分通过调节PI3K信号通路产生的。
