Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
Natl Toxicol Program Tech Rep Ser. 2018 Aug(593). doi: 10.22427/NTP-TR-593.
2,3-Butanedione is commonly used by the flavor manufacturing industry for production of artificial flavor formulations. Examples of flavored food products include popcorn, cake mixes, flour, beer, wine, margarines and soft spreads, cheese, candy, bakery products, crackers, cookies, ice cream, frozen foods, and many other food and beverage products. 2,3-Butanedione was nominated by the United Food and Commercial Workers Union for long-term inhalation studies due to outbreaks of bronchiolitis obliterans in workers exposed to its vapors. Male and female Wistar Han [Crl:WI(Han)] rats and B6C3F1/N mice were exposed to 2,3-butanedione (greater than or equal to 98.5%) by inhalation for 3 months or 2 years. Genetic toxicology studies were conducted in Salmonella typhimurium and Escherichia coli, mouse bone marrow cells, and rat and mouse peripheral blood erythrocytes. (Abstract Abridged).
2,3-丁二酮常用于香料制造行业，用于生产人工香料配方。调味食品的例子包括爆米花、蛋糕预拌粉、面粉、啤酒、葡萄酒、人造黄油和软涂抹酱、奶酪、糖果、烘焙食品、饼干、曲奇、冰淇淋、冷冻食品以及许多其他食品和饮料产品。由于接触其蒸气的工人爆发闭塞性细支气管炎，联合食品和商业工人联盟提名对2,3-丁二酮进行长期吸入研究。将雄性和雌性Wistar Han [Crl:WI(Han)]大鼠和B6C3F1/N小鼠通过吸入方式暴露于2,3-丁二酮（≥98.5%）中3个月或2年。在鼠伤寒沙门氏菌和大肠杆菌、小鼠骨髓细胞以及大鼠和小鼠外周血红细胞中进行了遗传毒理学研究。（摘要节略）
