Division of Translational Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
Toxic Rep Ser. 2023 Mar(98). doi: 10.22427/NTP-TOX-98.
Acetoin and 2,3-pentanedione are highly volatile components of artificial butter flavoring (ABF). Concerns over the inhalation toxicity of these compounds originate from the association between occupational exposures to ABF and adverse fibrotic lung effects, specifically obliterative bronchiolitis (OB) in the distal airways. 2,3-Pentanedione has been used as a replacement for 2,3-butanedione (diacetyl) in some ABF due to concerns about the respiratory toxicity of 2,3-butanedione. However, 2,3-pentanedione is structurally similar to 2,3-butanedione and has been shown to exhibit potency similar to 2,3-butanedione regarding airway toxicity following acute inhalation (whole-body) exposure. This report describes a series of studies to evaluate the 2-week inhalation toxicity of acetoin and the 3-month inhalation toxicity of acetoin and 2,3-pentanedione. (Abstract Abridged).
乙酰丙酮和 2,3-戊二酮是人工奶油香精（ABF）中高度挥发性的成分。人们对这些化合物吸入毒性的关注源于职业接触 ABF 与不良纤维性肺效应之间的关联，特别是远端气道的闭塞性细支气管炎（OB）。由于对 2,3-丁二酮（双乙酰）的呼吸道毒性的担忧，2,3-戊二酮已被用于一些 ABF 中替代 2,3-丁二酮。然而，2,3-戊二酮在结构上与 2,3-丁二酮相似，并且在急性吸入（全身）暴露后表现出与 2,3-丁二酮类似的气道毒性。本报告描述了一系列研究，以评估乙酰丙酮的 2 周吸入毒性，以及乙酰丙酮和 2,3-戊二酮的 3 个月吸入毒性。（摘要摘要）。
