Department of Endodontics, West China School of Stomatology, Sichuan University, Chengdu, China.
Curr Stem Cell Res Ther. 2021;16(8):915-923. doi: 10.2174/1574888X16666210203110354.
Bone is a hard but dynamic organ that is constantly remodeled throughout the life process. The dynamic balance between bone resorption and bone formation is very important. Mesenchymal stem cells (MSCs) have self-renewal and pluripotent differentiation; therefore, their roles as the promising tool for the treatment of osteoporosis and other diseases have become the focus in regenerative medicine in recent years. Over the past years, histone methylation has been recognized as a major player in the regulation of osteogenic differentiation of MSC. In this review, we highlight the recent research progress of histone methylation modification and its possible involvement in MSC osteogenesis.
骨骼是一种坚硬但具有活力的器官，在整个生命过程中不断进行重塑。骨吸收和骨形成之间的动态平衡非常重要。间充质干细胞（MSCs）具有自我更新和多能分化的能力；因此，近年来，它们作为治疗骨质疏松症和其他疾病的有前途的工具，成为再生医学的研究热点。在过去的几年中，组蛋白甲基化已被认为是调节 MSC 成骨分化的主要因素之一。在这篇综述中，我们强调了组蛋白甲基化修饰的最新研究进展及其在 MSC 成骨中的可能参与。
