Mohamed Fatima E, Aldayem Leena N, Hemaida Maisa A, Siddig Omayma, Osman Zeinab H, Shafig Irene R, Salih Mohamed A M, Muneer Mohamed S, Hassan Rowa, Ahmed Eiman Siddig, Hassan Lamis Ahmed, Bakheet Osama El Hadi, Edris Ali M M, Ahmed Ayman, Mohamed Nouh S, Siddig Emmanuel E
Department of Histopathology and Cytology, Faculty of Medical Laboratory Sciences, University of Khartoum, Khartoum, Sudan.
Department of Oral Pathology, Faculty of Dentistry, University of Khartoum, Khartoum, Sudan.
BMC Res Notes. 2021 Feb 9;14(1):56. doi: 10.1186/s13104-021-05471-5.
Human papillomavirus (HPV) gained momentum as a potential etiological factor for many types of cancers. Therefore, the aim of this study was to assess the prevalence of HPV-16 infection among Sudanese patients diagnosed with Squamous Cell Carcinoma (SCC) and Salivary Gland Carcinoma. A descriptive, hospital-based study was conducted. 150 formalin-fixed paraffin-embedded blocks were collected.
The study population included a total of 150 patients aged between 18 to 87 years with a mean age of 48.8 ± 11.9 years. Based on gender, females constituted 46.7% while males constituted 53.3%. The 150 patients were classified into 40 (26.0%) esophageal, 30 (20.0%) nasopharyngeal, 18 (12.0%) conjunctival, 18 (12.0%) tongue 12 (8.0%) laryngeal, 8 (5.3%) lip, 6 (4.0%) oropharyngeal, 6 (4.0%) mucoepidermoid, and 6 (4.0%) adenoid cystic, and 6 (4.0%) myoepithelial carcinomas. Odds ratio for male and female diagnosed with carcinoma was 1.025 [0.439-2.394, 95% CI]. Molecular detection of HPV-16 revealed a prevalence of 26 (17.3%) patients were positive for HPV-16. According to cancer diagnosis, esophageal SCC patients showed a high proportion of HPV-16; 14/40 (35.0%). A statistically significant difference was seen for the distribution of HPV-16 positive patients based on cancer diagnosis, P value 0.001.
人乳头瘤病毒（HPV）作为多种癌症潜在的病因因素，受到越来越多的关注。因此，本研究旨在评估被诊断为鳞状细胞癌（SCC）和唾液腺癌的苏丹患者中HPV - 16感染的流行情况。开展了一项基于医院的描述性研究。收集了150个福尔马林固定石蜡包埋组织块。
研究人群共150例患者，年龄在18至87岁之间，平均年龄为48.8±11.9岁。按性别划分，女性占46.7%，男性占53.3%。150例患者分为40例（26.0%）食管癌、30例（20.0%）鼻咽癌、18例（12.0%）结膜癌、18例（12.0%）舌癌、12例（8.0%）喉癌、8例（5.3%）唇癌、6例（4.0%）口咽癌、6例（4.0%）黏液表皮样癌、6例（4.0%）腺样囊性癌和6例（4.0%）肌上皮癌。男性和女性被诊断为癌症的优势比为1.025 [0.439 - 2.394，95%置信区间]。HPV - 16的分子检测显示，26例（17.3%）患者HPV - 16呈阳性。根据癌症诊断，食管癌SCC患者中HPV - 16的比例较高；14/40（35.0%）。基于癌症诊断，HPV - 16阳性患者的分布存在统计学显著差异，P值为0.001。
