Department of Pathology & Immunology, St. Louis, MO 63110, USA.
Department of Pathology & Immunology, St. Louis, MO 63110, USA.
Trends Immunol. 2021 Mar;42(3):180-182. doi: 10.1016/j.it.2021.01.008. Epub 2021 Feb 6.
The nervous system plays important roles in homeostasis and inflammatory responses in tissues. However, the regulation of lymph nodes (LN) by nerves remains largely unknown. Huang et al. demonstrate that LNs are innervated by unique peptidergic nociceptors that signal to various endothelial, stromal, and immune cell types in LNs.
神经系统在组织的体内平衡和炎症反应中起着重要作用。然而，神经对淋巴结（LN）的调节在很大程度上尚不清楚。Huang 等人证明，LN 由独特的肽能伤害感受器支配，这些感受器向 LN 中的各种内皮细胞、基质细胞和免疫细胞类型发出信号。
