Zou Mangge, Wiechers Carolin, Huehn Jochen
Department Experimental Immunology, Helmholtz Centre for Infection Research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Department Experimental Immunology, Helmholtz Centre for Infection Research, Inhoffenstr. 7, 38124 Braunschweig, Germany; Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
Int J Med Microbiol. 2021 Apr;311(3):151492. doi: 10.1016/j.ijmm.2021.151492. Epub 2021 Feb 25.
The effective priming of adaptive immune responses depends on the precise dispatching of lymphocytes and antigens into and within lymph nodes (LNs), which are strategically dispersed throughout the body. Over the past decade, a growing body of evidence has advanced our understanding of lymph node stromal cells (LNSCs) from viewing them as mere accessory cells to seeing them as critical cellular players for the modulation of adaptive immune responses. In this review, we summarize current advances on the pivotal roles that LNSCs play in orchestrating adaptive immune responses during homeostasis and infection, and highlight the imprinting of location-specific information by micro-environmental cues into LNSCs, thereby tailoring tissue-specific immune responses.
适应性免疫反应的有效启动取决于淋巴细胞和抗原精确地输送到淋巴结（LN）内并在其中移动，淋巴结在全身呈策略性分布。在过去十年中，越来越多的证据使我们对淋巴结基质细胞（LNSC）的理解不断深入，从仅仅将它们视为辅助细胞，到将它们视为调节适应性免疫反应的关键细胞参与者。在这篇综述中，我们总结了LNSC在稳态和感染期间协调适应性免疫反应中所起关键作用的当前进展，并强调了微环境线索将位置特异性信息印记到LNSC中，从而定制组织特异性免疫反应。
