Welch I M, Sepple C P, Read N W
Sub-Department of Gastrointestinal Physiology and Nutrition, University of Sheffield, Royal Hallamshire Hospital.
Gut. 1988 Mar;29(3):306-11. doi: 10.1136/gut.29.3.306.
Food intake and feelings of hunger and fullness were monitored in paired studies carried out in two groups of six healthy non-obese male volunteers during infusion of isotonic solutions of either a 50% corn oil emulsion or saline into the jejunum or into the ileum. Infusion of the lipid emulsion at a rate of 1.2 ml/min (4.9 kcal/min) into either the ileum or the jejunum significantly reduced the period of eating (p less than 0.01) and the quantity of food consumed (p less than 0.01), but neither affected the rates of drinking or the amount of fluid consumed. Infusion of the lipid emulsion into the jejunum also significantly reduced the sensations of hunger before the meal (p less than 0.05), and the rate of ingestion (p less than 0.01). Ileal infusion did not influence these indices. The results suggest that jejunal and ileal infusion of lipid reduces the size of the meal that could be consumed possibly by inhibiting gastric emptying. The alleviation of hunger before ingestion and the slower rate of eating, however, suggests that jejunal lipid activates an additional mechanism that influences the appetite centre in the hypothalamus directly.
在两组每组六名健康非肥胖男性志愿者中进行了配对研究，在向空肠或回肠输注50%玉米油乳剂或生理盐水等渗溶液期间，监测食物摄入量以及饥饿和饱腹感。以1.2毫升/分钟（4.9千卡/分钟）的速率向回肠或空肠输注脂质乳剂，显著缩短了进食时间（p<0.01）和食物摄入量（p<0.01），但对饮水速率或液体摄入量均无影响。向空肠输注脂质乳剂还显著减轻了餐前饥饿感（p<0.05）和进食速率（p<0.01）。回肠输注对这些指标无影响。结果表明，空肠和回肠输注脂质可能通过抑制胃排空来减少可摄入食物的量。然而，摄入前饥饿感的减轻和进食速率的减慢表明，空肠脂质激活了一种额外机制，直接影响下丘脑的食欲中枢。
