Gibbs J, Maddison S P, Rolls E T
J Comp Physiol Psychol. 1981 Dec;95(6):1003-15. doi: 10.1037/h0077845.
A sham-feeding preparation utilizing rhesus monkeys was employed to investigate the anatomical site of origin of satiety signals in the gastrointestinal tract. A series of experiments in which food was diverted from the stomach, the small intestine, or both demonstrated that (a) food acting at the pregastric level is not sufficient to produce normal-sized meals, (b) the accumulation of food in the small intestine is necessary to produce normal-sized meals, and (c) a potent preabsorptive or postabsorptive satiety signal originates at the intestinal level. This unidentified satiety signal is sufficient to elicit satiety, can be dissociated from gastric emptying, and does not require the presence of gastric distention to operate.
利用恒河猴进行假饲准备，以研究胃肠道饱腹感信号的解剖学起源部位。一系列将食物从胃、小肠或两者分流的实验表明：（a）作用于胃前水平的食物不足以产生正常量的进食；（b）小肠中食物的积累对于产生正常量的进食是必要的；（c）一种有效的吸收前或吸收后饱腹感信号起源于肠道水平。这种未明确的饱腹感信号足以引发饱腹感，可以与胃排空分离，且其发挥作用不需要胃扩张的存在。
