Institute of Computer Science, University of Tartu, Tartu, Tartumaa, 51009, Estonia.
F1000Res. 2020 Jul 15;9. doi: 10.12688/f1000research.24956.2. eCollection 2020.
g:Profiler ( https://biit.cs.ut.ee/gprofiler) is a widely used gene list functional profiling and namespace conversion toolset that has been contributing to reproducible biological data analysis already since 2007. Here we introduce the accompanying R package, , developed to facilitate programmatic access to g:Profiler computations and databases via REST API. The package provides an easy-to-use functionality that enables researchers to incorporate functional enrichment analysis into automated analysis pipelines written in R. The package also implements interactive visualisation methods to help to interpret the enrichment results and to illustrate them for publications. In addition, gives access to the versatile gene/protein identifier conversion functionality in g:Profiler enabling to map between hundreds of different identifier types or orthologous species. The package is freely available at the CRAN repository.
g:Profiler(https://biit.cs.ut.ee/gprofiler)是一个广泛使用的基因列表功能分析和命名空间转换工具集,自 2007 年以来一直为可重复的生物数据分析做出贡献。在这里,我们介绍了配套的 R 包 ,它是为了通过 REST API 方便地访问 g:Profiler 的计算和数据库而开发的。该包提供了一个易于使用的功能,使研究人员能够将功能富集分析纳入用 R 编写的自动化分析管道中。该包还实现了交互式可视化方法,以帮助解释富集结果并为出版物进行说明。此外, 还提供了 g:Profiler 中的多功能基因/蛋白质标识符转换功能,能够在数百种不同的标识符类型或同源物种之间进行映射。 包可在 CRAN 存储库中免费获得。