癌症免疫疗法导致的膜性肾病复发
Relapse of membranous nephropathy with cancer immunotherapy.
作者信息
Kim Youngho
机构信息
Pacific Nephrology Associates, Tacoma, WA, USA.
出版信息
Clin Kidney J. 2019 Jun 21;14(1):418-420. doi: 10.1093/ckj/sfz074. eCollection 2021 Jan.
Abstract
Advances in monoclonal antibody technology have enabled the application of engineered antibodies to interfere with specific immune pathways. Checkpoint inhibitors have shown promising results in treating certain cancers by employing patients' own immune systems to attack cancer cells. Checkpoint inhibitors release the brake on the immune system and can cause immune-related diseases. Theoretically this could be disadvantageous in patients with autoimmune diseases. Here I describe a case of nephrotic syndrome relapse in a patient with a history of membranous nephropathy during programmed death-ligand 1 inhibitor therapy for lung cancer. It is postulated that enhancement of the immune system triggered the relapse of nephrotic syndrome by leading to an escape of immune tolerance and increased susceptibility.
摘要
单克隆抗体技术的进步使得工程抗体能够应用于干扰特定的免疫途径。检查点抑制剂通过利用患者自身的免疫系统攻击癌细胞，在治疗某些癌症方面已显示出有前景的结果。检查点抑制剂解除了免疫系统的刹车，可能导致免疫相关疾病。从理论上讲，这在自身免疫性疾病患者中可能是不利的。在此，我描述了一例肺癌患者在接受程序性死亡配体1抑制剂治疗期间，患有膜性肾病病史的肾病综合征复发的病例。据推测，免疫系统的增强通过导致免疫耐受的逃逸和易感性增加，引发了肾病综合征的复发。
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本文引用的文献
1
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Arch Immunol Ther Exp (Warsz). 2018 Apr;66(2):133-143. doi: 10.1007/s00005-017-0485-3. Epub 2017 Aug 2.
2
Adverse Renal Effects of Immune Checkpoint Inhibitors: A Narrative Review.免疫检查点抑制剂的肾脏不良反应：一项叙述性综述
Am J Nephrol. 2017;45(2):160-169. doi: 10.1159/000455014. Epub 2017 Jan 12.
3
Anti-phospholipase A2 receptor antibodies and malignancy in membranous nephropathy.抗磷脂酶A2受体抗体与膜性肾病中的恶性肿瘤
Am J Kidney Dis. 2013 Dec;62(6):1223-5. doi: 10.1053/j.ajkd.2013.07.019. Epub 2013 Sep 8.
4
Programmed death 1 ligand (PD-L) 1 and PD-L2 limit autoimmune kidney disease: distinct roles.程序性死亡1配体（PD-L）1和PD-L2限制自身免疫性肾脏疾病：不同作用。
J Immunol. 2007 Dec 1;179(11):7466-77. doi: 10.4049/jimmunol.179.11.7466.
5
Prognosis after a complete remission in adult patients with idiopathic membranous nephropathy.特发性膜性肾病成年患者完全缓解后的预后
Am J Kidney Dis. 1999 Jun;33(6):1026-32. doi: 10.1016/S0272-6386(99)70138-1.
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