David Constanta, Efanov Johnny I, Borsuk Daniel E
Plastic and Reconstructive Surgery service, Centre Hospitalier Universitaire Sainte-Justine, University of Montreal, Montreal, Canada.
Faculty of Dentistry, McGill University, Montreal, Canada.
Plast Reconstr Surg Glob Open. 2021 Jan 22;9(1):e3311. doi: 10.1097/GOX.0000000000003311. eCollection 2021 Jan.
Our objective was to determine the potential impact of the surgical treatment of ameloblastoma in children through validated health state utility outcome measures.
A survey-based preference health utility assessment using the visual analog scale, time trade-off, and standard gamble methods was undertaken among a general population sample. Quality-adjusted life years were derived from these measures. A one-way ANOVA was used for statistical analysis, with a mean () value of 0.05 considered significant. Demographic parameters were individually assessed as possible predictors of each utility score.
In total, 86 participants took part in this study, with a mean age of 29.9 years. Greater utility scores were observed among participants reporting no religious beliefs ( = 0.025, = 2.28). No other demographic parameters showed statistically significant prediction of utility score. From the mean utility scores (± SD) (visual analog scale = 0.60 ± 0.17; time trade-off = 0.65 ± 0.22; standard gamble = 0.64 ± 0.20), a gain of 30.0, 32.3, and 32.1 quality-adjusted life years may be derived, respectively. All utility outcome measures suggested that an ameloblastoma during childhood is perceived as more burdensome than several debilitating conditions, such as cleft lip and palate.
To attain perfect health, participants would theoretically undergo surgical treatment of an ameloblastoma during childhood, with willingness to trade off 28.2 years of life and accepting a 35.7% risk of death. The objective assessment of the perceived burden of an ameloblastoma affliction during childhood may inspire cost-utility or cost-effectiveness analyses at broader societal levels.
我们的目标是通过经过验证的健康状态效用结果测量方法，确定儿童成釉细胞瘤手术治疗的潜在影响。
在一般人群样本中，采用视觉模拟量表、时间权衡法和标准博弈法进行基于调查的偏好健康效用评估。从这些测量方法中得出质量调整生命年。使用单因素方差分析进行统计分析，均值（）值为0.05被认为具有统计学意义。将人口统计学参数作为每个效用得分的可能预测因素进行单独评估。
共有86名参与者参与了本研究，平均年龄为29.9岁。在报告无宗教信仰的参与者中观察到更高的效用得分（=0.025，=2.28）。没有其他人口统计学参数显示对效用得分有统计学意义的预测。根据平均效用得分（±标准差）（视觉模拟量表=0.60±0.17；时间权衡法=0.65±0.22；标准博弈法=0.64±0.20），分别可得出30.0、32.3和32.1个质量调整生命年的增益。所有效用结果测量方法均表明，儿童期的成釉细胞瘤比唇腭裂等几种使人衰弱的疾病被认为负担更重。
为了达到完美健康，理论上参与者愿意接受儿童期成釉细胞瘤的手术治疗，愿意权衡28.2年的生命，并接受35.7%的死亡风险。对儿童期成釉细胞瘤折磨的感知负担进行客观评估，可能会激发更广泛社会层面的成本效用或成本效益分析。
