Nakayama Satoru, Tsuge Itaru, Katsuragawa Hiroyuki, Fujimoto Masakazu, Fujimori Hideyuki, Katsube Motoki, Sakamoto Michiharu, Morimoto Naoki
Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Department of Diagnostic Pathology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Plast Reconstr Surg Glob Open. 2021 Jan 26;9(1):e3375. doi: 10.1097/GOX.0000000000003375. eCollection 2021 Jan.
A 48-year-old man with a protruding tumor on the parietal region had undergone treatment of alopecia using artificial synthetic fibers 2 or 3 times a year for 10 years from 30 to 39 years old. Three months before the first consultation at our hospital, he noticed a small tumor that had gradually shown bleeding and discharge, with expansion of the affected area. A diagnosis of squamous cell carcinoma (SCC) was made based on a biopsy, and we resected the tumor with a 1-cm surgical margin from the reddened area around the protruding tumor (14 × 11 cm), including the periosteum membrane. No tight adhesion was found between the periosteum and skull, so we excised the outer table of the skull of the central part (diameter: 8 cm) for a pathological analysis. A pathological study showed moderately differentiated SCC with a negative surgical margin. The whole tumor was surrounded by scar tissue with buried artificial hair implants. The second surgery was performed on the 15 postoperative day. An anterolateral thigh flap was divided into 2 flaps to fit the circle-shaped wound. This is the second report of SCC developing after artificial hair implantation in the frontal-parietal scalp. The whole protruding tumor was surrounded by scar tissue with buried artificial hair implants. Proving the direct causal relationship between inflammation of scar tissue and SCC generation is difficult; however, our pathological findings support the possibility of the harmful effects of artificial hair implants.
一名48岁男性，顶叶区域有一突出肿瘤，在30至39岁期间每年使用人工合成纤维治疗脱发2至3次，共10年。在我院首次就诊前3个月，他注意到一个小肿瘤，逐渐出现出血和分泌物，且病变区域扩大。经活检诊断为鳞状细胞癌（SCC），我们从突出肿瘤周围发红区域（14×11厘米）包括骨膜切除肿瘤，手术切缘为1厘米。未发现骨膜与颅骨之间有紧密粘连，因此我们切除了中央部分颅骨外板（直径：8厘米）进行病理分析。病理研究显示为中度分化的SCC，手术切缘阴性。整个肿瘤被埋有人造毛发植入物的瘢痕组织包围。术后第15天进行了第二次手术。将股前外侧皮瓣分成2个皮瓣以适应圆形伤口。这是额顶部头皮人工毛发植入后发生SCC的第二篇报道。整个突出肿瘤被埋有人造毛发植入物的瘢痕组织包围。很难证明瘢痕组织炎症与SCC发生之间存在直接因果关系；然而，我们的病理结果支持人造毛发植入物有害影响的可能性。
