Patterson R, Harris K E, Stopford W, Van der Heiden G, Grammer L C, Bunn W
Department of Medicine, Northwestern University Medical School, Chicago, Ill.
Int Arch Allergy Appl Immunol. 1988;85(4):467-71. doi: 10.1159/000234553.
An evaluation of workers in a plant was conducted because of multiple complaints of ocular, nasal, skin and chest symptoms. Antibody activity against 4 different chemicals was identified: an aliphatic diisocyanate, 4-vinylcyclohexene dioxide, trimellitic anhydride (TMA) and an unknown chemical present in a plasticizing ester known as n-octyl-n-decyl-trimellitate. The source of TMA which resulted in immunization in the plant is unknown. The presence or absence of antibodies did not correlate with the presence or absence of symptoms and it was concluded that no occupational allergic disease was present in these workers. Antibody studies alone do not make a diagnosis of occupational allergic disease and clinical correlation is required. Immunoassays may be useful in identifying exposures to immunizing chemicals in the workplace for potential clinical correlation or for exposure monitoring in the workplace.
由于多名工人出现眼部、鼻部、皮肤和胸部症状的投诉，对一家工厂的工人进行了评估。确定了针对4种不同化学物质的抗体活性：一种脂肪族二异氰酸酯、4-乙烯基环己烯二氧化物、偏苯三酸酐（TMA）以及一种存在于名为正辛基-正癸基-偏苯三酸酯的增塑酯中的未知化学物质。导致该工厂工人免疫的TMA来源不明。抗体的存在与否与症状的有无并无关联，得出的结论是这些工人不存在职业性过敏性疾病。仅靠抗体研究不能诊断职业性过敏性疾病，还需要临床关联。免疫测定法在识别工作场所中接触免疫化学物质方面可能有用，以便进行潜在的临床关联或工作场所的接触监测。
