Boxer M B, Grammer L C, Harris K E, Roach D E, Patterson R
J Allergy Clin Immunol. 1987 Aug;80(2):147-52. doi: 10.1016/0091-6749(87)90123-0.
We report a 6-year study from 1979 through 1985 of workers exposed to trimellitic anhydride (TMA) in three groups of volunteers. Twenty-nine percent of workers (5/17) originally studied had immunologically induced respiratory disease. Subsequent to this evaluation, increased environmental control of TMA exposure was instituted. Since that time, there have been decreasing clinical symptoms and decreasing levels of antibody against TMA conjugated to human serum albumin. These long-term studies originally used radioimmunoassays, but enzyme-linked immunoassays against TMA-conjugated proteins are now demonstrated to be equally appropriate and are more cost-effective. With appropriate clinical and immunologic studies, immunologic airway reactions to TMA may be identified and then prevented by environmental control to decrease inhalation exposure to TMA. This is likely applicable to certain other chemical antigens that immunize by inhalation.
我们报告了一项从1979年至1985年对三组接触偏苯三酸酐（TMA）的志愿者进行的为期6年的研究。最初研究的工人中有29%（5/17）患有免疫性诱发的呼吸道疾病。在此次评估之后，加强了对TMA暴露的环境控制。从那时起，临床症状逐渐减轻，与结合人血清白蛋白的TMA的抗体水平也逐渐降低。这些长期研究最初使用放射免疫测定法，但现在已证明针对TMA结合蛋白的酶联免疫测定法同样适用且更具成本效益。通过适当的临床和免疫学研究，可以识别出对TMA的免疫性气道反应，然后通过环境控制减少吸入TMA暴露来预防。这可能适用于某些其他通过吸入引起免疫反应的化学抗原。
