Pediatrics, Department of Clinical Sciences, Umeå University, Umeå, Sweden.
Department of Psychology, Umeå University, Umeå, Sweden.
Am J Clin Nutr. 2021 Mar 11;113(3):586-592. doi: 10.1093/ajcn/nqaa354.
We previously reported results from a randomized controlled trial in which we found that Swedish infants consuming an experimental low-energy, low-protein formula (EF) supplemented with bovine milk fat globule membranes (MFGMs) until 6 mo of age had several positive outcomes, including better performance in the cognitive domain of Bayley Scales of Infant and Toddler Development 3rd Edition at 12 mo of age, and higher plasma cholesterol concentrations during the intervention, than infants consuming standard formula (SF).
We aimed to evaluate neurodevelopment, growth, and plasma cholesterol status at 6 and 6.5 y of age in the same study population.
We assessed cognitive and executive functions using the Wechsler Intelligence Scale for Children 4th Edition (WISC-IV), Brown Attention-Deficit Disorder Scales for Children and Adolescents (Brown-ADD), and Quantified Behavior (Qb) tests, and behavior using the Child Behavior Checklist (CBCL) and Teacher's Report Form (TRF), at 6.5 y of age. Anthropometrics and plasma lipids were assessed at 6 y of age.
There were no differences between the EF and SF groups in any of the subscales in WISC-IV or Brown-ADD at 6.5 y of age, in the proportion of children with scores outside the normal range in the Qb test, nor in clinical or borderline indications of problems in adaptive functioning from parental and teacher's scoring using the CBCL and TRF. There were no differences between the EF and SF groups in weight, length, or head or abdominal circumferences, nor in plasma concentrations of homocysteine, lipids, insulin, or glucose.
Among children who as infants consumed a low-energy, low-protein formula supplemented with bovine MFGMs, there were no effects on neurodevelopment, growth, or plasma cholesterol status 6-6.5 y later.
我们之前报告了一项随机对照试验的结果，该试验发现，食用低能量、低蛋白配方（EF）并补充牛乳脂肪球膜（MFGM）的瑞典婴儿，在 6 个月大时，与食用标准配方（SF）的婴儿相比，在婴儿和幼儿发展的贝利量表第 3 版的认知领域表现更好，在干预期间，血浆胆固醇浓度更高。
我们旨在评估同一研究人群在 6 岁和 6.5 岁时的神经发育、生长和血浆胆固醇状况。
我们使用韦氏儿童智力量表第 4 版（WISC-IV）、布朗注意缺陷障碍量表儿童和青少年版（Brown-ADD）和量化行为（Qb）测试评估认知和执行功能，以及在 6.5 岁时使用儿童行为检查表（CBCL）和教师报告表（TRF）评估行为。在 6 岁时评估人体测量学和血浆脂质。
在 WISC-IV 或 Brown-ADD 的任何子量表中，EF 和 SF 组在 6.5 岁时，在 Qb 测试中得分超出正常范围的儿童比例，以及在使用 CBCL 和 TRF 进行的父母和教师评分的适应性功能临床或边界问题方面，均无差异。在体重、身高或头围或腹围，以及血浆同型半胱氨酸、脂质、胰岛素或葡萄糖浓度方面，EF 和 SF 组之间也无差异。
在婴儿期食用低能量、低蛋白配方并补充牛乳 MFGM 的儿童中，6-6.5 年后神经发育、生长或血浆胆固醇状况没有影响。
