Clinical Sciences/Pediatrics, Umeå University, Umeå, Sweden.
Steno Diabetes Center Copenhagen, Gentofte, Denmark.
Pediatr Res. 2018 Nov;84(5):726-732. doi: 10.1038/s41390-018-0130-9. Epub 2018 Aug 4.
Supplementation of formula with bovine milk fat globule membranes has been shown to narrow the gap in immunological and cognitive development between breast-fed and formula-fed infants.
In a double-blinded randomized controlled trial 160 formula-fed infants received an experimental formula (EF), supplemented with bovine milk fat globule membranes, or standard formula until 6 months of age. A breast-fed reference group was recruited. Lipidomic analyses were performed on plasma and erythrocyte membranes at 6 months and on serum at 4 and 12 months of age.
At 6 months of age, we observed a significant separation in the plasma lipidome between the two formula groups, mostly due to differences in concentrations of sphingomyelins (SM), phosphatidylcholines (PC), and ceramides, and in the erythrocyte membrane lipidome, mostly due to SMs, PEs and PCs. Already at 4 months, a separation in the serum lipidome was evident where SMs and PCs contributed. The separation was not detected at 12 months.
The effect of MFGM supplementation on the lipidome is likely part of the mechanisms behind the positive cognitive and immunological effects of feeding the EF previously reported in the same study population.
研究表明，在配方奶粉中添加牛乳脂肪球膜可以缩小母乳喂养和配方奶喂养婴儿在免疫和认知发育方面的差距。
在一项双盲随机对照试验中，160 名配方奶喂养的婴儿在 6 个月大之前接受了添加牛乳脂肪球膜的实验性配方奶粉（EF）或标准配方奶粉的喂养。同时招募了母乳喂养的参考组。在 6 个月时对血浆和红细胞膜进行脂质组学分析，并在 4 个月和 12 个月时对血清进行脂质组学分析。
在 6 个月大时，我们观察到两个配方组的血浆脂质组明显分离，主要是由于鞘磷脂（SM）、磷脂酰胆碱（PC）和神经酰胺的浓度差异，以及红细胞膜脂质组，主要是由于 SMs、PEs 和 PCs 的差异。在 4 个月时，血清脂质组已经出现分离，其中 SM 和 PC 有贡献。在 12 个月时未检测到分离。
MFGM 补充对脂质组的影响可能是该研究人群中先前报道的 EF 喂养对认知和免疫产生积极影响的部分机制。
