B 族维生素治疗糖尿病疼痛和神经病变。
B vitamins as a treatment for diabetic pain and neuropathy.
机构信息
Department of Life, Earth, and Environmental Science, West Texas A&M University, Canyon, TX, USA.
SUSTech Center for Pain Medicine and the Medical School, Southern University of Science and Technology, Shenzhen, China.
出版信息
J Clin Pharm Ther. 2021 Oct;46(5):1199-1212. doi: 10.1111/jcpt.13375. Epub 2021 Feb 9.
WHAT IS KNOWN AND OBJECTIVE
B vitamin therapy is a common treatment for diabetic pain and neuropathy, yet its use remains controversial in patients lacking B vitamin deficiencies. The aim of this review was to summarize the current evidence for the efficacy of B vitamin therapy in diabetic patients with neuropathy.
COMMENT
We screened the English literature for clinical studies evaluating B vitamins as a therapy for pain and neuropathy in diabetic patients. We selected 43 relevant studies for qualitative analysis based on our selection criteria. Our survey of the literature revealed substantive heterogeneity with respect to efficacies of reported outcomes, as well as study design. Most beneficial outcomes were reported against baseline measures, with few positive comparisons against placebo. This highlights the need for larger, placebo-controlled studies.
WHAT IS NEW AND CONCLUSION
B vitamins should be considered a plausible therapy for diabetic neuropathy, but its overall efficacy remains uncertain and requires further study.
已知和目的
维生素 B 治疗是治疗糖尿病疼痛和神经病变的常用方法，但在缺乏维生素 B 缺乏症的患者中，其使用仍存在争议。本综述的目的是总结目前关于维生素 B 治疗糖尿病神经病变患者疼痛的疗效的证据。
评论
我们在英文文献中筛选了评估维生素 B 作为治疗糖尿病患者疼痛和神经病变的治疗方法的临床研究。根据我们的选择标准，我们选择了 43 项相关研究进行定性分析。我们对文献的调查显示，报告的结果疗效以及研究设计存在实质性的异质性。大多数有益的结果是与基线测量相比报告的，与安慰剂相比，阳性比较很少。这突出表明需要更大规模的安慰剂对照研究。
新内容和结论
维生素 B 应被视为治疗糖尿病性神经病变的合理方法，但总体疗效仍不确定，需要进一步研究。
Zotero 插件