State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810008, China.
J Asian Nat Prod Res. 2021 Nov;23(11):1068-1076. doi: 10.1080/10286020.2021.1880395. Epub 2021 Feb 10.
Polycyclic polyprenylated acylphloroglucinols (PPAPs) were mainly obtained from the plants of genus of Guttiferae family, and possessed intriguing chemical structures and appealing biological activities. Two new PPAPs derivatives, hyperacmosin C () and hyperacmosin D () were isolated from . Their structures were established by NMR, HREIMS, and experimental electronic circular dichroism spectra. Besides, compound showed significant hepatoprotective activity at 10 µM against paracetamol-induced HepG2 cell damage and compound could moderately increase the relative glucose consumption.
多环多聚异戊烯基酰基间苯三酚（PPAPs）主要来源于藤黄科金丝桃属植物，具有有趣的化学结构和诱人的生物活性。从 hypericum 中分离得到了两个新的 PPAPs 衍生物，hyperacmosin C（）和 hyperacmosin D（）。它们的结构通过 NMR、HREIMS 和实验电子圆二色谱光谱确定。此外，化合物在 10 μM 时对扑热息痛诱导的 HepG2 细胞损伤显示出显著的保肝活性，化合物能适度增加相对葡萄糖消耗。
