来自……的三种新的多环多异戊烯基化酰基间苯三酚衍生物——高阿克莫辛H-J
Hyperacmosins H-J, three new polycyclic polyprenylated acylphloroglucinol derivatives from .
作者信息
Wang Xue, Wang Jia-Jia, Suo Xin-Yue, Sun Hao-Ran, Zhen Bo, Sun Hua, Li Jian-Guang, Ji Teng-Fei
机构信息
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
College of Pharmacy, Xinjiang Medical University, Urumqi 830011, China.
出版信息
J Asian Nat Prod Res. 2020 Jun;22(6):521-530. doi: 10.1080/10286020.2020.1739662. Epub 2020 Mar 18.
Three new polycyclic polyprenylated acylphloroglucinol derivatives, hyperacmosins H-J (), with four known compounds (), were isolated from the air-dried aerial parts of . Especially, compounds and were identified as methylated polycyclic polyprenylated acylphloroglucinol derivatives (mPPAPs). Their structures were established by NMR, HRESIMS and experimental electronic circular dichroism (ECD) spectra. The hepatoprotective activity of seven compounds were evaluated. Compounds and exhibited hepatoprotective activity against paracetamol-induced HepG2 cell damage.[Formula: see text].
从[植物名称]的风干地上部分分离出三种新的多环多异戊烯基酰基间苯三酚衍生物，即hyperacmosins H-J（[具体结构或编号]），以及四种已知化合物（[具体结构或编号]）。特别地，化合物[具体编号]和[具体编号]被鉴定为甲基化多环多异戊烯基酰基间苯三酚衍生物（mPPAPs）。通过核磁共振（NMR）、高分辨电喷雾电离质谱（HRESIMS）和实验性电子圆二色光谱（ECD）对其结构进行了确证。评估了七种化合物的保肝活性。化合物[具体编号]和[具体编号]对扑热息痛诱导的HepG2细胞损伤表现出保肝活性。[分子式：见原文]
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