Department of internal Medicine, Head and Neck Surgery, Faculty of Medicine, Zagazig University, Sharkia Governorate, Egypt.
Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Zagazig University, Sharkia Governorate, Egypt.
Saudi J Kidney Dis Transpl. 2020 Nov-Dec;31(6):1303-1309. doi: 10.4103/1319-2442.308339.
Myringosclerosis is the final stage of the middle ear lamina propria inflammation or trauma; it starts with collagen production in excess amounts in the lamina propria of the middle ear mucosa. Then, hyalinization and calcification occur. Later on, metaplasia of bone or cartilage can occur. A similar sequence occurs with hyperparathyroidism in chronic kidney disease. This study is aimed to detect the prevalence of myringosclerosis in patients of our hemodialysis (HD) unit and find out any association between hyperparathyroidism and myringosclerosis in chronic HD patients. A total number of 86 patients were selected according to the inclusion criteria. They were divided into two groups: Group 1 (58 patients myringosclerosis free patients on regular HD), Group 2 (28 patients myringosclerosis-positive patients on regular HD). No statically significant difference was found in serum parathyroid hormone levels between the two studied groups. Serum creatinine was significantly higher in Group 2, serum ferritin was significantly lower in Group 2, and mean corpuscular volume of red blood cells was highly significantly lower in Group 2. Myringosclerosis affects 32% of our HD patients and we could not detect any strong correlation between myringosclerosis and hyperparathyroidism.
鼓膜硬化症是中耳固有层炎症或创伤的终末阶段;它始于中耳黏膜固有层内胶原的过量产生。然后发生玻璃样变和钙化。后来,可能发生骨或软骨的化生。慢性肾脏病中的甲状旁腺功能亢进症也会出现类似的序列。本研究旨在检测我们血液透析(HD)单位患者中耳硬化症的患病率,并找出慢性 HD 患者甲状旁腺功能亢进症与鼓膜硬化症之间的任何关联。根据纳入标准,共选择了 86 名患者。他们被分为两组:第 1 组(58 名定期接受 HD 治疗且无鼓膜硬化症的患者)和第 2 组(28 名定期接受 HD 治疗且有鼓膜硬化症的患者)。两组之间的血清甲状旁腺激素水平无统计学差异。第 2 组的血清肌酐显著升高,第 2 组的血清铁蛋白显著降低,第 2 组的红细胞平均体积显著降低。鼓膜硬化症影响了我们 32%的 HD 患者,但我们未能检测到鼓膜硬化症和甲状旁腺功能亢进症之间有任何强相关性。