Caldas Neto Silvio, Lessa Fábio José Delgado, Alves Gabriel, Caldas Nelson, Gouveia Mariana de Carvalho Leal
Pernambuco Federal University (UFPE).
Braz J Otorhinolaryngol. 2008 Jul-Aug;74(4):494-502. doi: 10.1016/s1808-8694(15)30594-2.
Myringosclerosis is a scar of the tympanic membrane lamina propria, resulting from trauma or inflammation, characterized by proliferation of collagen, hyalinization, calcium and phosphate deposits and cartilaginous or osseous metaplasia of the middle ear mucosa, a sequence that is similar to that taking place in other types of pathologic calcification, common in chronic renal failure (CRF).
To verify the influence of chronic renal failure on the prevalence of myringosclerosis.
The otoscopic examination was done in 341 chronic renal failure patients and in 356 normal control individuals. The frequency of positive otoscopies was compared between the two groups, based on individual variables and those pertaining to CRF.
11.7% of the patients had a positive otoscopy in the CRF group, compared to 5.1% in the control group. There was no statistical difference in the frequency of myringosclerosis according to gender, ethnic group, time of dialysis or serum minerals. The groups had a wide age range.
Although the findings of this study suggest a higher occurrence of myringosclerosis in patients with renal disease, they do not provide a basis for stating that there is any relation between renal failure and tympanic alterations.
鼓室硬化是鼓膜固有层的瘢痕,由创伤或炎症引起,其特征为胶原增生、玻璃样变、钙和磷沉积以及中耳黏膜的软骨化生或骨化生,这一过程类似于其他类型的病理性钙化,常见于慢性肾衰竭(CRF)。
验证慢性肾衰竭对鼓室硬化患病率的影响。
对341例慢性肾衰竭患者和356例正常对照个体进行耳镜检查。根据个体变量和与慢性肾衰竭相关的变量,比较两组耳镜检查阳性的频率。
慢性肾衰竭组11.7%的患者耳镜检查呈阳性,而对照组为5.1%。根据性别、种族、透析时间或血清矿物质,鼓室硬化的频率无统计学差异。两组年龄范围广泛。
尽管本研究结果提示肾病患者鼓室硬化的发生率较高,但并未提供证据表明肾衰竭与鼓膜改变之间存在任何关联。