Malasala Satyaveni, Polomoni Anusha, Chelli Sai Manohar, Kar Swayamsidda, Madhavi Y V, Nanduri Srinivas
Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500 037, India.
Department of Process Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500 037, India.
Org Biomol Chem. 2021 Mar 4;19(8):1854-1859. doi: 10.1039/d0ob02312d.
A method for the microwave-assisted copper-mediated oxidative coupling reaction of different aldehydes and quinazolines/benzimidazoles has been developed for the synthesis of fused-polycyclic systems via new C-N bond formation. The current methodology involves the use of environmentally benign NH4OAc as the amine source in the presence of 2-propanol as the solvent. This novel tandem reaction approach offers a rapid and straightforward access to complex fused quinazoline derivatives in an efficient manner.
一种用于不同醛与喹唑啉/苯并咪唑的微波辅助铜介导氧化偶联反应的方法已被开发出来，用于通过形成新的C-N键来合成稠合多环体系。当前的方法涉及在2-丙醇作为溶剂的存在下，使用环境友好的醋酸铵作为胺源。这种新颖的串联反应方法以高效的方式提供了一种快速且直接合成复杂稠合喹唑啉衍生物的途径。
