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纳米凝胶作为药物载体的制备和应用。

Preparation and use of nanogels as carriers of drugs.

机构信息

Key Laboratory of Analytical Science and Technology of Hebei Province, College of Chemistry & Environmental Science, Hebei University, Baoding, China.

Department of Chemistry, Sri Krishnadevaraya University, Anantapur, India.

出版信息

Drug Deliv. 2021 Dec;28(1):1594-1602. doi: 10.1080/10717544.2021.1955042.

DOI:10.1080/10717544.2021.1955042
PMID:34308729
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8317930/
Abstract

Nanogels have high tunability and stability while being able to sense and respond to external stimuli by showing changes in the gel volume, water content, colloidal stability, mechanical strength, and other physical/chemical properties. In this article, advances in the preparation of nanogels will be reviewed. The application potential of nanogels in drug delivery will also be highlighted. It is the objective of this article to present a snapshot of the recent knowledge of nanogel preparation and application for future research in drug delivery.

摘要

纳米凝胶具有高的可调性和稳定性,同时能够通过凝胶体积、含水量、胶体稳定性、机械强度和其他物理/化学性质的变化来感知和响应外部刺激。本文将综述纳米凝胶的制备进展。纳米凝胶在药物传递中的应用潜力也将得到强调。本文的目的是呈现纳米凝胶制备和应用的最新知识快照,为药物传递的未来研究提供参考。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a94d/8317930/03dfc1141e80/IDRD_A_1955042_F0004_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a94d/8317930/fcc80bb07919/IDRD_A_1955042_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a94d/8317930/9562ced2aaf4/IDRD_A_1955042_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a94d/8317930/0c66c12a44a5/IDRD_A_1955042_F0003_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a94d/8317930/03dfc1141e80/IDRD_A_1955042_F0004_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a94d/8317930/fcc80bb07919/IDRD_A_1955042_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a94d/8317930/9562ced2aaf4/IDRD_A_1955042_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a94d/8317930/0c66c12a44a5/IDRD_A_1955042_F0003_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a94d/8317930/03dfc1141e80/IDRD_A_1955042_F0004_C.jpg

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ACS Appl Mater Interfaces. 2021 Mar 24;13(11):12928-12940. doi: 10.1021/acsami.1c00136. Epub 2021 Mar 12.
3
Gels. 2025 Apr 4;11(4):267. doi: 10.3390/gels11040267.
4
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AAPS PharmSciTech. 2025 Mar 4;26(3):74. doi: 10.1208/s12249-025-03063-1.
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