Department of Biotechnology, Faculty of Science, B N University, Udaipur, Raj., India.
Appl Biochem Biotechnol. 2021 Jun;193(6):1631-1638. doi: 10.1007/s12010-021-03518-8. Epub 2021 Feb 10.
The present study encompasses in vitro immunomodulatory activity of Withania somnifera WS (Solanaceae) examined on human neutrophils. The isolated compound of Withania somnifera roots was screened for its possible immunomodulatory activity by nitro blue tetrazolium test, phagocytosis of killed Candida albicans, neutrophil locomotion and chemotaxis. The extracted compound was examined at concentrations, viz. 10 μg/ml, 20 μg/ml, 40 μg/ml, 100 μg/ml and 1000 μg/ml. The activity expressed by the compound on human neutrophils was found to be significant for examined parameters.
本研究考察了睡茄（茄科）的体外免疫调节活性对人嗜中性粒细胞的影响。通过硝基蓝四唑试验、吞噬已杀死的白色念珠菌、嗜中性粒细胞迁移和趋化性，筛选了睡茄根的分离化合物，以检测其可能的免疫调节活性。在所检查的浓度下，即在 10μg/ml、20μg/ml、40μg/ml、100μg/ml 和 1000μg/ml 下，检查了提取的化合物。该化合物对人嗜中性粒细胞的活性在检查的参数中表现出显著的效果。
