Rao C S, Raju C, Gopumadhavan S, Chauhan B L, Kulkarni R D, Mitra S K
R & D Centre, Himalaya Drug Co, Makali, Bangalore, India.
Indian J Exp Biol. 1994 Aug;32(8):553-8.
Effect of Septilin, an ayurvedic formulation proven to be effective in the therapy of chronic infections, was investigated on the phagocytic system and humoral response in rats and mice. Septilin exhibited significant protection in E. coli-induced abdominal sepsis in normal mice and in Staphylococcus aureus-induced sepsis in neutropenic mice. It significantly reduced the viable E. coli cells when incubated with neutrophils in rats. Septilin stimulated the phagocytic function of the reticuloendothelial system in mice. In normal rats, Septilin enhanced anti-SRBC hemagglutination antibody titre by 5.7-fold and showed significant protection in cyclophosphamide-induced humoral suppression.
已证实一种阿育吠陀配方药物Septilin在慢性感染治疗中有效，本研究考察了其对大鼠和小鼠吞噬系统及体液反应的影响。Septilin对正常小鼠的大肠杆菌诱导的腹部脓毒症以及中性粒细胞减少小鼠的金黄色葡萄球菌诱导的脓毒症均表现出显著的保护作用。在大鼠中，它与中性粒细胞一起孵育时能显著减少存活的大肠杆菌细胞。Septilin刺激了小鼠网状内皮系统的吞噬功能。在正常大鼠中，Septilin使抗SRBC血凝抗体滴度提高了5.7倍，并在环磷酰胺诱导的体液抑制中表现出显著的保护作用。
